Detection of mucosal abnormalities in patients with oral cancer using a photodynamic technique: a pilot study

Martin O'Dwyer, Adam Day, Miles Padgett, G. R. Ogden, S. McLaren, Carol R. Goodman

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Patients who have had one oral cancer are at increased risk of developing a further malignant tumour, the detection of which is made difficult (and is often delayed) by the innocuous appearance of the early oral lesion. A technique that could reliably detect early cancers would be useful to both oral and dental health specialists. We describe a pilot study in which we used a compact spectroscopic instrument designed to excite and measure fluorescence in the oral cavity. The data were processed using principal components analysis, and the results suggest that the technique might be valuable for detecting early oral cancers. Further work should be performed to investigate some unusual characteristics observed within our data to ascertain if these are significant, simply due to errors made due data collection, or are due to other lifestyle factors. Such work could also verify that the data are due to detection of ALA metabolite in cancer and not some other systemic effect. (c) 2007 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)6-10
    Number of pages5
    JournalBritish Journal of Oral and Maxillofacial Surgery
    Volume46
    Issue number1
    DOIs
    Publication statusPublished - Jan 2008

    Keywords

    • Photodynamic detection
    • Oral cancer
    • Biopsy

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