Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays

Search results

• Finished

  Method Development for Quantitative Assessment of Protein Turnover in Live Cells at Subcellular Resolution

  Dinkova-Kostova, A. (Investigator), Muqit, M. (Investigator) & Saurin, A. (Investigator)

  1/03/18 → 31/12/19

  Project: Research

  • Transcription Factor Nrf2 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 81%
  • Kelch-like ECH-associated Protein 1 (Keap1) 63%
  • Nrf2 Activator 47%
  • Electrophile 38%

• The Role of the Keap1/Nrf2 Pathway in Tumour Metabolic Adaptation (Joint with University of Cambridge and University College London)

  Dinkova-Kostova, A. (Investigator)

  1/06/15 → 30/04/21

  Project: Research

  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Transcription Factor Nrf2 83%
  • Kelch-like 58%
  • Associated Proteins 58%
  • Synapsin I 57%

• The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

  Dinkova-Kostova, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  30/09/14 → 27/02/18

  Project: Research

  • Transcription Factor Nrf2 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 79%
  • Synapsin I 48%
  • Kelch-like 30%
  • Associated Proteins 30%