TY - JOUR
T1 - Developing core elements and checklist items for global hospital antimicrobial stewardship programmes
T2 - a consensus approach
AU - Pulcini, Céline
AU - Binda, Francesca
AU - Lamkang, Anjana Sankhil
AU - Trett, Anna
AU - Charani, Esmita
AU - Goff, Debra A.
AU - Harbarth, Stephan
AU - Hinrichsen, Sylvia Lemos
AU - Levy-Hara, Gabriel
AU - Mendelson, Marc
AU - Nathwani, Dilip
AU - Gunturu, Revathi
AU - Singh, Sanjeev
AU - Srinivasan, Arjun
AU - Thamlikitkul, Visanu
AU - Thursky, Karin
AU - Vlieghe, Erika
AU - Wertheim, Heiman
AU - Zeng, Mei
AU - Gandra, Sumanth
AU - Laxminarayan, Ramanan
N1 - SG received a grant from the WISH foundation (http://www.wish-qatar.org) to compensate for his time on this project. This work will be presented at the WISH forum, and travel costs for CP, FB, SG, and RL to the forum will be covered by the WISH foundation. However, the funder had no role in the conduct of our research.
PY - 2019/1
Y1 - 2019/1
N2 - Objectives: With increasing global interest in hospital antimicrobial stewardship (AMS) programmes, there is a strong demand for core elements of AMS to be clearly defined on the basis of principles of effectiveness and affordability. To date, efforts to identify such core elements have been limited to Europe, Australia, and North America. The aim of this study was to develop a set of core elements and their related checklist items for AMS programmes that should be present in all hospitals worldwide, regardless of resource availability.Methods: A literature review was performed by searching Medline and relevant websites to retrieve a list of core elements and items that could have global relevance. These core elements and items were evaluated by an international group of AMS experts using a structured modified Delphi consensus procedure, using two-phased online in-depth questionnaires.Results: The literature review identified seven core elements and their related 29 checklist items from 48 references. Fifteen experts from 13 countries in six continents participated in the consensus procedure. Ultimately, all seven core elements were retained, as well as 28 of the initial checklist items plus one that was newly suggested, all with ≥80% agreement; 20 elements and items were rephrased.Conclusions: This consensus on core elements for hospital AMS programmes is relevant to both high- and low-to-middle-income countries and could facilitate the development of national AMS stewardship guidelines and adoption by healthcare settings worldwide.
AB - Objectives: With increasing global interest in hospital antimicrobial stewardship (AMS) programmes, there is a strong demand for core elements of AMS to be clearly defined on the basis of principles of effectiveness and affordability. To date, efforts to identify such core elements have been limited to Europe, Australia, and North America. The aim of this study was to develop a set of core elements and their related checklist items for AMS programmes that should be present in all hospitals worldwide, regardless of resource availability.Methods: A literature review was performed by searching Medline and relevant websites to retrieve a list of core elements and items that could have global relevance. These core elements and items were evaluated by an international group of AMS experts using a structured modified Delphi consensus procedure, using two-phased online in-depth questionnaires.Results: The literature review identified seven core elements and their related 29 checklist items from 48 references. Fifteen experts from 13 countries in six continents participated in the consensus procedure. Ultimately, all seven core elements were retained, as well as 28 of the initial checklist items plus one that was newly suggested, all with ≥80% agreement; 20 elements and items were rephrased.Conclusions: This consensus on core elements for hospital AMS programmes is relevant to both high- and low-to-middle-income countries and could facilitate the development of national AMS stewardship guidelines and adoption by healthcare settings worldwide.
KW - Antimicrobial resistance
KW - Antimicrobial stewardship
KW - Hospital
KW - Low-income country
KW - Middle-income country
U2 - 10.1016/j.cmi.2018.03.033
DO - 10.1016/j.cmi.2018.03.033
M3 - Article
C2 - 29625170
SN - 1198-743X
VL - 25
SP - 20
EP - 25
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 1
ER -
