Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging

Praveen C. Ashok, Bavishna B. Praveen, Martin Rube, Benjamin Cox, Andreas Melzer, Kishan Dholakia

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Raman spectroscopy has proven to be a powerful tool for discriminating between normal and abnormal tissue types. Fiber based Raman probes have demonstrated its potential for in vivo disease diagnostics. Combining Raman spectroscopy with Magnetic Resonance Imaging (MRI) opens up new avenues for MR guided minimally invasive optical biopsy. Although Raman probes are commercially available, they are not compatible with a MRI environment due to the metallic components which are used to align the micro-optic components such as filters and lenses at the probe head. Additionally they are not mechanically compatible with a typical surgical environment as factors such as sterility and length of the probe are not addressed in those designs. We have developed an MRI compatible fiber Raman probe with a disposable probe head hence maintaining sterility. The probe head was specially designed to avoid any material that would cause MR imaging artefacts. The probe head that goes into patient’s body had a diameter <1.5 mm so that it is compatible with biopsy needles and catheters. The probe has been tested in MR environment and has been proven to be capable of obtaining Raman signal while the probe is under real-time MR guidance.
    Original languageEnglish
    Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems XII
    EditorsTuan Vo-Dinh, Anita Mahadevan-Jensen, Warren S. Grundfest
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9780819498489
    DOIs
    Publication statusPublished - 2014
    EventSPIE Photonics West 2014: Advanced Biomedical and Clinical Diagnostic Systems XII - The Moscone Center, San Francisco, United States
    Duration: 2 Feb 20144 Feb 2014
    http://spie.org/x106299.xml

    Publication series

    NameProceedings of SPIE
    Volume8935
    ISSN (Print)1605-7422
    NameProgress in Biomedical Optics and Imaging
    PublisherSPIE
    Number10
    Volume15

    Conference

    ConferenceSPIE Photonics West 2014: Advanced Biomedical and Clinical Diagnostic Systems XII
    CountryUnited States
    CitySan Francisco
    Period2/02/144/02/14
    Internet address

    Keywords

    • Surgical guidance
    • Cancer detection
    • Fiber
    • Raman probe
    • Interventional Magnetic Resonance Imaging
    • Magnetic Resonance Imaging
    • Raman spectroscopy

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  • Cite this

    Ashok, P. C., Praveen, B. B., Rube, M., Cox, B., Melzer, A., & Dholakia, K. (2014). Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging. In T. Vo-Dinh, A. Mahadevan-Jensen, & W. S. Grundfest (Eds.), Advanced Biomedical and Clinical Diagnostic Systems XII [89351J ] (Proceedings of SPIE; Vol. 8935), (Progress in Biomedical Optics and Imaging; Vol. 15, No. 10). SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2039805