Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging

TY - GEN

T1 - Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging

AU - Ashok, Praveen C.

AU - Praveen, Bavishna B.

AU - Rube, Martin

AU - Cox, Benjamin

AU - Melzer, Andreas

AU - Dholakia, Kishan

N1 - Export Date: 14 April 2014 Source: Scopus Art. No.: 89351J

PY - 2014

Y1 - 2014

N2 - Raman spectroscopy has proven to be a powerful tool for discriminating between normal and abnormal tissue types. Fiber based Raman probes have demonstrated its potential for in vivo disease diagnostics. Combining Raman spectroscopy with Magnetic Resonance Imaging (MRI) opens up new avenues for MR guided minimally invasive optical biopsy. Although Raman probes are commercially available, they are not compatible with a MRI environment due to the metallic components which are used to align the micro-optic components such as filters and lenses at the probe head. Additionally they are not mechanically compatible with a typical surgical environment as factors such as sterility and length of the probe are not addressed in those designs. We have developed an MRI compatible fiber Raman probe with a disposable probe head hence maintaining sterility. The probe head was specially designed to avoid any material that would cause MR imaging artefacts. The probe head that goes into patient’s body had a diameter <1.5 mm so that it is compatible with biopsy needles and catheters. The probe has been tested in MR environment and has been proven to be capable of obtaining Raman signal while the probe is under real-time MR guidance.

AB - Raman spectroscopy has proven to be a powerful tool for discriminating between normal and abnormal tissue types. Fiber based Raman probes have demonstrated its potential for in vivo disease diagnostics. Combining Raman spectroscopy with Magnetic Resonance Imaging (MRI) opens up new avenues for MR guided minimally invasive optical biopsy. Although Raman probes are commercially available, they are not compatible with a MRI environment due to the metallic components which are used to align the micro-optic components such as filters and lenses at the probe head. Additionally they are not mechanically compatible with a typical surgical environment as factors such as sterility and length of the probe are not addressed in those designs. We have developed an MRI compatible fiber Raman probe with a disposable probe head hence maintaining sterility. The probe head was specially designed to avoid any material that would cause MR imaging artefacts. The probe head that goes into patient’s body had a diameter <1.5 mm so that it is compatible with biopsy needles and catheters. The probe has been tested in MR environment and has been proven to be capable of obtaining Raman signal while the probe is under real-time MR guidance.

KW - Surgical guidance

KW - Cancer detection

KW - Fiber

KW - Raman probe

KW - Interventional Magnetic Resonance Imaging

KW - Magnetic Resonance Imaging

KW - Raman spectroscopy

U2 - 10.1117/12.2039805

DO - 10.1117/12.2039805

M3 - Conference contribution

SN - 9780819498489

T3 - Proceedings of SPIE

BT - Advanced Biomedical and Clinical Diagnostic Systems XII

A2 - Vo-Dinh, Tuan

A2 - Mahadevan-Jensen, Anita

A2 - Grundfest, Warren S.

PB - SPIE-International Society for Optical Engineering

CY - Bellingham

T2 - SPIE Photonics West 2014: Advanced Biomedical and Clinical Diagnostic Systems XII

Y2 - 2 February 2014 through 4 February 2014

ER -