Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

Keyphrases

• Biological Samples 100%
• Liquid Chromatography-electrospray Ionization-mass Spectrometry (LC-ESI-MS) 100%
• Intrastrand Cross-link 100%
• Mass Spectrometry Methods 100%
• Oxaliplatin 100%
• Guanine 80%
• Liver 40%
• No Significant Difference 20%
• Lung 20%
• Purine 20%
• MS-MS 20%
• Cell Resistance 20%
• Null Mice 20%
• Glutathione S-transferase 20%
• Kidney 20%
• Mouse Strain 20%
• DNA Sequencing 20%
• Lung Tissue 20%
• Limit of Detection 20%
• MS Method 20%
• Cytotoxic Activity 20%
• Cellular DNA 20%
• Tandem Mass Spectrometry 20%
• Platinum-based Chemotherapy 20%
• Pt-based 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Electrospray Ionization 100%
• Oxaliplatin 100%
• Guanine 80%
• Adenine 40%
• Chemotherapy 20%
• Purine 20%
• Knockout Mouse 20%
• Glutathione Transferase 20%
• Mouse Strain 20%
• Cell DNA 20%
• DNA Base 20%
• Cytotoxicity 20%