Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

Search results

• Finished

  Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

  Alessi, D. (Investigator)

  1/08/19 → 30/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • LRRK2 76%
  • PPM1H 38%
  • Rab Proteins 36%
  • Phosphatase 33%

• Bench-to-Bedside Parkinson's Disease Research: Biomarkers in LRRK2 (NHS Research Scotland (NRS) and Scottish Universities Scottish Senior Clinical Academic Fellowship Scheme)

  Sammler, E. (Investigator)

  7/01/19 → 30/06/24

  Project: Research

  • Parkinson's Disease 100%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 90%
  • Kinase 78%
  • Phosphotransferase 78%
  • Leucine-Rich Repeat 71%

• Regulation of the Parkinson's kinase LRRK2

  Alessi, D. (Investigator)

  Parkinson's UK

  3/09/18 → 2/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Leucine-Rich Repeat 91%
  • Kinase 85%
  • Phosphotransferase 85%
  • Parkinson's Disease 41%

• Towards a Unifying Theory of Parkinson's Disease - Investigation of the Biochemical and Genetic Role of Rab GTPases (joint with German Centre for Neurodegenerative Diseases)

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  Medical Research Council

  17/10/16 → 16/10/18

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Leucine-Rich Repeat 64%
  • Kinase 61%
  • Phosphotransferase 61%
  • LRRK2 50%