Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial

Fraser Stewart, Ian P. Newton, Benjamin F. Cox, Zhihong Huang, Inke Nathke, Sandy Cochran

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.

Original languageEnglish
Number of pages1
DOIs
Publication statusPublished - 2 Nov 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: 6 Sep 20179 Sep 2017

Conference

Conference2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period6/09/179/09/17

Fingerprint

endoscopes
capsules
seats
ablation
delivery
drugs
dosage
radiation

Keywords

  • Endoscopes
  • Transducers
  • Drug delivery
  • Fluorescence
  • Immune system
  • Gastrointestinal tract
  • Testing

Cite this

Stewart, F., Newton, I. P., Cox, B. F., Huang, Z., Nathke, I., & Cochran, S. (2017). Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States. https://doi.org/10.1109/ULTSYM.2017.8092467
Stewart, Fraser ; Newton, Ian P. ; Cox, Benjamin F. ; Huang, Zhihong ; Nathke, Inke ; Cochran, Sandy. / Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract : Bench testing to translational trial. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States.1 p.
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abstract = "Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.",
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Stewart, F, Newton, IP, Cox, BF, Huang, Z, Nathke, I & Cochran, S 2017, 'Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial', Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 6/09/17 - 9/09/17. https://doi.org/10.1109/ULTSYM.2017.8092467

Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract : Bench testing to translational trial. / Stewart, Fraser; Newton, Ian P.; Cox, Benjamin F.; Huang, Zhihong; Nathke, Inke; Cochran, Sandy.

2017. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States.

Research output: Contribution to conferencePaper

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T1 - Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract

T2 - Bench testing to translational trial

AU - Stewart, Fraser

AU - Newton, Ian P.

AU - Cox, Benjamin F.

AU - Huang, Zhihong

AU - Nathke, Inke

AU - Cochran, Sandy

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Y1 - 2017/11/2

N2 - Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.

AB - Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.

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KW - Transducers

KW - Drug delivery

KW - Fluorescence

KW - Immune system

KW - Gastrointestinal tract

KW - Testing

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Stewart F, Newton IP, Cox BF, Huang Z, Nathke I, Cochran S. Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial. 2017. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States. https://doi.org/10.1109/ULTSYM.2017.8092467