Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial

Fraser Stewart; Ian P. Newton; Benjamin F. Cox; Zhihong Huang; Inke Nathke; Sandy Cochran

doi:10.1109/ULTSYM.2017.8092467

Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial

Fraser Stewart, Ian P. Newton, Benjamin F. Cox, Zhihong Huang, Inke Nathke, Sandy Cochran

Research output: Contribution to conference › Paper › peer-review

3 Citations (Scopus)

Abstract

Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.

Original language	English
Number of pages	1
DOIs	https://doi.org/10.1109/ULTSYM.2017.8092467
Publication status	Published - 2 Nov 2017
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: 6 Sept 2017 → 9 Sept 2017

Conference

Conference	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/Territory	United States
City	Washington
Period	6/09/17 → 9/09/17

Keywords

Endoscopes
Transducers
Drug delivery
Fluorescence
Immune system
Gastrointestinal tract
Testing

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2017.8092467

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)
Cochran, S. (Investigator), Corner, G. (Investigator), Cuschieri, A. (Investigator), Nathke, I. (Investigator) & Steele, B. (Investigator)
Engineering and Physical Sciences Research Council
27/05/13 → 14/12/18
Project: Research

Cite this

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title = "Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial",

abstract = "Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.",

keywords = "Endoscopes, Transducers, Drug delivery, Fluorescence, Immune system, Gastrointestinal tract, Testing",

author = "Fraser Stewart and Newton, {Ian P.} and Cox, {Benjamin F.} and Zhihong Huang and Inke Nathke and Sandy Cochran",

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T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017

AU - Stewart, Fraser

AU - Newton, Ian P.

AU - Cox, Benjamin F.

AU - Huang, Zhihong

AU - Nathke, Inke

AU - Cochran, Sandy

PY - 2017/11/2

Y1 - 2017/11/2

N2 - Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.

AB - Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.

KW - Endoscopes

KW - Transducers

KW - Drug delivery

KW - Fluorescence

KW - Immune system

KW - Gastrointestinal tract

KW - Testing

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DO - 10.1109/ULTSYM.2017.8092467

M3 - Paper

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Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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Projects

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this