Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial

Fraser Stewart, Ian P. Newton, Benjamin F. Cox, Zhihong Huang, Inke Nathke, Sandy Cochran

Research output: Contribution to conferencePaperpeer-review

2 Citations (Scopus)

Abstract

Video capsule endoscopy (VCE) is a widely accepted clinical alternative to conventional endoscopy for diagnosis in the gut. Its advantages are that it can visualise the entire gastrointestinal tract including the small bowel (SB) and it is less invasive for the patient. However, VCE is suitable only for diagnosis, with little research into therapeutic capsule endoscopy (TCE). Like VCE, TCE has great potential to reach locations that would previously have been difficult, such as the SB. Ultrasound-mediated targeted drug delivery (UmTDD) is a promising modality for TCE: the power required is low compared with ultrasound (US) ablation and focused US can manipulate the position of therapeutic agents using radiation forces, increase uptake into and through cell layers, and thus deliver a higher dose safely to specifically targeted sites of action.

Original languageEnglish
Number of pages1
DOIs
Publication statusPublished - 2 Nov 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: 6 Sep 20179 Sep 2017

Conference

Conference2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period6/09/179/09/17

Keywords

  • Endoscopes
  • Transducers
  • Drug delivery
  • Fluorescence
  • Immune system
  • Gastrointestinal tract
  • Testing

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