Development of the spatial representation system in the rat

Rosamund F. Langston, James A. Ainge, Jonathan J. Couey, Cathrin B. Canto, Tale L. Bjerknes, Menno P. Witter, Edvard I. Moser (Lead / Corresponding author), May-Britt Moser

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    361 Citations (Scopus)

    Abstract

    In the adult brain, space and orientation are represented by an elaborate hippocampal-parahippocampal circuit consisting of head-direction cells, place cells, and grid cells. We report that a rudimentary map of space is already present when 21/2-week-old rat pups explore an open environment outside the nest for the first time. Head-direction cells in the pre- and parasubiculum have adultlike properties from the beginning. Place and grid cells are also present but evolve more gradually. Grid cells show the slowest development. The gradual refinement of the spatial representation is accompanied by an increase in network synchrony among entorhinal stellate cells. The presence of adultlike directional signals at the onset of navigation raises the possibility that such signals are instrumental in setting up networks for place and grid representation.

    Original languageEnglish
    Pages (from-to)1576-1580
    Number of pages5
    JournalScience
    Volume328
    Issue number5985
    DOIs
    Publication statusPublished - 18 Jun 2010

    Keywords

    • ENTORHINAL CORTEX
    • PLACE CELLS
    • GRID CELLS
    • PATH-INTEGRATION
    • MAP
    • MODEL
    • HIPPOCAMPUS
    • DIRECTION

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