Developmental regulation of lumenal lung fluid and electrolyte transport

Stuart Wilson, Richard Olver, D. V. Walters

    Research output: Contribution to journalReview article

    32 Citations (Scopus)

    Abstract

    In the fetus, there is a net secretion of liquid (LL) by the lung as a result of active transport of chloride ions. The rate of secretion and the resulting volume of LL are vital for normal lung growth but how volume is sensed and how secretion may be regulated are still unknown. Towards term under the influence of thyroid and adrenocorticoid hormones, the epithelial sodium channel (ENaC) is increasingly expressed in the pulmonary epithelium. Adrenaline released by the fetus during labour activates ENaC and produces rapid absorption of liquid in preparation for air breathing; absence of ENaC is incompatible with survival. There may be other mechanisms involved in aiding liquid clearance including changes in epithelial permeability, an effect of oxygen on both ENaC and Na/K ATPase and perhaps the influence of additional hormones on ENaC activity. Some time after birth there are further developmental changes with the appearance of other cation channels (CNG1 and perhaps NSCC) which contribute to the liquid absorptive side of the balance existing across the epithelium between secretion and absorption to produce essentially almost no net liquid movement in the postnatal lung. The evidence for these processes is discussed and areas of uncertainty indicated. (C) 2007 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)247-255
    Number of pages9
    JournalRespiratory Physiology & Neurobiology
    Volume159
    Issue number3
    DOIs
    Publication statusPublished - 15 Dec 2007

    Keywords

    • lung
    • ion
    • transport
    • liquid clearance
    • perinatal maturation
    • FETAL GUINEA-PIGS
    • EPITHELIAL NA+ CHANNEL
    • LIQUID REABSORPTIVE MECHANISM
    • RESPIRATORY-DISTRESS SYNDROME
    • CLC-2 CHLORIDE CHANNEL
    • PRODUCTION IN-VITRO
    • ION-TRANSPORT
    • BIOPHYSICAL PROPERTIES
    • SODIUM-CHANNEL
    • ALPHA-SUBUNIT

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