TY - JOUR
T1 - Developmental trends in cord and postpartum serum thyroid hormones in preterm infants
AU - Williams, Fiona L. R.
AU - Simpson, Judith
AU - Delahunty, Caroline
AU - Ogston, Simon A.
AU - Bongers-Schokking, Jacoba J.
AU - Murphy, Nuala
AU - van Toor, Hans
AU - Wu, Sing-Yung
AU - Visser, Theo J.
AU - Hume, Robert
AU - Scottish Preterm Thyroid Group
N1 - dc.publisher: The Endocrine Society
Joint Principal Investigator, planned and directed work, analysed data, jointly wrote manuscript, member of multi-disciplinary CEC programme, which this paper is one of the outputs. This is the most detailed world series of data on human thyroid hormones in the fetus and infant.
PY - 2004
Y1 - 2004
N2 - The purpose of this study was first to clarify postnatal trends in sera T-4, free T-4 (FT4), T-4-binding globulin, TSH, T-3, rT(3), and T-4 sulfate levels in cord and at 7, 14, and 28 d in groups of preterm infants at 23-27 wk (n = 101), 28-30 wk (n = 196), and 31-34 (n = 253) wk gestation, and second to compare these trends to those of term infants and also with cord sera levels of equivalent gestational ages (n = 812; 23-42 wk gestation). In all preterm groups, TSH and rT(3) decrease to below, T-4-binding globulin increases to within, and T-3 and T-4 sulfate increase to above cord levels of equivalent gestational age. Term infants are hyperthyroxinemic relative to cord and nonpregnant adult levels of T-4. Postnatal T-4 increases are attenuated in 31- to 34-wk infants, absent in 28- to 30-wk infants (although levels are equivalent to gestational age), and crucially reversed in 23- to 27-wk infants. This immature group is hypothyroxinemic relative to other groups and to cord levels of equivalent gestational age. Compared with term infants, postnatal FT4 increases are lower in 31- to 34-wk infants, attenuated in 28- to 30-wk infants, and absent in 23- to 27-wk infants. The 23- to 27-wk group is distinctive; they are hypothyroxinemic on T-4 levels, yet FT4 levels are within the cord levels of equivalent gestational age.
AB - The purpose of this study was first to clarify postnatal trends in sera T-4, free T-4 (FT4), T-4-binding globulin, TSH, T-3, rT(3), and T-4 sulfate levels in cord and at 7, 14, and 28 d in groups of preterm infants at 23-27 wk (n = 101), 28-30 wk (n = 196), and 31-34 (n = 253) wk gestation, and second to compare these trends to those of term infants and also with cord sera levels of equivalent gestational ages (n = 812; 23-42 wk gestation). In all preterm groups, TSH and rT(3) decrease to below, T-4-binding globulin increases to within, and T-3 and T-4 sulfate increase to above cord levels of equivalent gestational age. Term infants are hyperthyroxinemic relative to cord and nonpregnant adult levels of T-4. Postnatal T-4 increases are attenuated in 31- to 34-wk infants, absent in 28- to 30-wk infants (although levels are equivalent to gestational age), and crucially reversed in 23- to 27-wk infants. This immature group is hypothyroxinemic relative to other groups and to cord levels of equivalent gestational age. Compared with term infants, postnatal FT4 increases are lower in 31- to 34-wk infants, attenuated in 28- to 30-wk infants, and absent in 23- to 27-wk infants. The 23- to 27-wk group is distinctive; they are hypothyroxinemic on T-4 levels, yet FT4 levels are within the cord levels of equivalent gestational age.
U2 - 10.1210/jc.2004-0869
DO - 10.1210/jc.2004-0869
M3 - Article
C2 - 15531476
SN - 0021-972X
VL - 89
SP - 5314
EP - 5320
JO - Journal of Clinical Endocrinology & Metabolism
JF - Journal of Clinical Endocrinology & Metabolism
IS - 11
ER -