Deviating from the norm: Nuclear organisation in trypanosomes

Mark C. Field (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
21 Downloads (Pure)

Abstract

At first glance the nucleus is a highly conserved organelle. Overall nuclear morphology, the octagonal nuclear pore complex, the presence of peripheral heterochromatin and the nuclear envelope appear near constant features right down to the ultrastructural level. New work is revealing significant compositional divergence within these nuclear structures and their associated functions, likely reflecting adaptations and distinct mechanisms between eukaryotic lineages and especially the trypanosomatids. While many examples of mechanistic divergence currently lack obvious functional interpretations, these studies underscore the malleability of nuclear architecture. I will discuss some recent findings highlighting these facets within trypanosomes, together with the underlying evolutionary framework and make a call for the exploration of nuclear function in non-canonical experimental organisms.
Original languageEnglish
Article number102234
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume85
Issue number12
Early online date2 Sept 2023
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Lamins
  • Lamina
  • Nuclear architecture
  • Nuclear envelope
  • Molecular evolution
  • Eukaryogenesis
  • Nuclear pore complex
  • Trypanosomes

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