Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

Albena T. Dinkova-Kostova, Jed W. Fahey, Andrea L. Benedict, Stephanie N. Jenkins, Lingxiang Ye, Scott L. Wehage, Paul Talalay

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    35 Citations (Scopus)

    Abstract

    Feeding broccoli sprout extracts providing daily doses of 10 mu mol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

    Original languageEnglish
    Pages (from-to)597-600
    Number of pages4
    JournalPhotochemical & Photobiological Sciences
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - 2010

    Keywords

    • MOUSE SKIN
    • SULFORAPHANE
    • INHIBITION
    • ISOTHIOCYANATES
    • TUMORIGENESIS
    • ANTIOXIDANTS
    • SUPPRESSION
    • ENZYMES
    • CANCER
    • TUMORS

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