Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

Albena T. Dinkova-Kostova; Jed W. Fahey; Andrea L. Benedict; Stephanie N. Jenkins; Lingxiang Ye; Scott L. Wehage; Paul Talalay

doi:10.1039/b9pp00130a

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

Albena T. Dinkova-Kostova
, Jed W. Fahey
, Andrea L. Benedict
, Stephanie N. Jenkins
, Lingxiang Ye
, Scott L. Wehage
, Paul Talalay

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Feeding broccoli sprout extracts providing daily doses of 10 mu mol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

Original language	English
Pages (from-to)	597-600
Number of pages	4
Journal	Photochemical & Photobiological Sciences
Volume	9
Issue number	4
DOIs	https://doi.org/10.1039/b9pp00130a
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

MOUSE SKIN
SULFORAPHANE
INHIBITION
ISOTHIOCYANATES
TUMORIGENESIS
ANTIOXIDANTS
SUPPRESSION
ENZYMES
CANCER
TUMORS

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title = "Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice",

abstract = "Feeding broccoli sprout extracts providing daily doses of 10 mu mol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70\%, respectively, in the animals that received the protective agent.",

keywords = "MOUSE SKIN, SULFORAPHANE, INHIBITION, ISOTHIOCYANATES, TUMORIGENESIS, ANTIOXIDANTS, SUPPRESSION, ENZYMES, CANCER, TUMORS",

author = "Dinkova-Kostova, \{Albena T.\} and Fahey, \{Jed W.\} and Benedict, \{Andrea L.\} and Jenkins, \{Stephanie N.\} and Lingxiang Ye and Wehage, \{Scott L.\} and Paul Talalay",

year = "2010",

doi = "10.1039/b9pp00130a",

language = "English",

volume = "9",

pages = "597--600",

journal = "Photochemical \& Photobiological Sciences",

issn = "1474-905X",

publisher = "Springer Nature",

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T1 - Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

AU - Dinkova-Kostova, Albena T.

AU - Fahey, Jed W.

AU - Benedict, Andrea L.

AU - Jenkins, Stephanie N.

AU - Ye, Lingxiang

AU - Wehage, Scott L.

AU - Talalay, Paul

PY - 2010

Y1 - 2010

N2 - Feeding broccoli sprout extracts providing daily doses of 10 mu mol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

AB - Feeding broccoli sprout extracts providing daily doses of 10 mu mol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.

KW - MOUSE SKIN

KW - SULFORAPHANE

KW - INHIBITION

KW - ISOTHIOCYANATES

KW - TUMORIGENESIS

KW - ANTIOXIDANTS

KW - SUPPRESSION

KW - ENZYMES

KW - CANCER

KW - TUMORS

U2 - 10.1039/b9pp00130a

DO - 10.1039/b9pp00130a

M3 - Article

C2 - 20354656

SN - 1474-905X

VL - 9

SP - 597

EP - 600

JO - Photochemical & Photobiological Sciences

JF - Photochemical & Photobiological Sciences

IS - 4

ER -

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

Abstract

UN SDGs

Keywords

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