Dietary sodium loading increases plasma brain natriuretic peptide levels in man

Chim C. Lang, Wendy J. Coutie, Teck K. Khong, Anna Maria Choy, Allan D Struthers

    Research output: Contribution to journalArticle

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    Abstract

    The effect of dietary sodium loading on plasma human brain natriuretic peptide-like immunoreactivity (hBNP-li) was examined in 11 normotensive subjects aged 20-23 years. Plasma hBNP-li increased significantly with increasing dietary sodium intake, with levels of 1.33 +/- 0.17 pmol/l on day 5 of a normal-sodium diet (24-h urinary sodium excretion of 171 +/- 16 mmol) and 2.04 +/- 0.10 pmol/l (P less than 0.05, versus normal-sodium diet) on day 5 of a high-sodium diet (24-h urinary sodium excretion 503 +/- 36 mmol). Corresponding plasma atrial natriuretic factor levels were 5.6 +/- 1.7 pmol/l and 11.0 +/- 2.0 pmol/l (P less than 0.05, versus normal-sodium diet) on the normal- and high-sodium diets, respectively. These results suggest that, in addition to atrial natriuretic factor, BNP may be a new and important natriuretic peptide which regulates sodium homeostasis in man during increased sodium intake.
    Original languageEnglish
    Pages (from-to)779-82
    Number of pages4
    JournalJournal of Hypertension
    Volume9
    Issue number9
    Publication statusPublished - 1991

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