TY - JOUR
T1 - Dietary strategies for maintenance of clinical remission in inflammatory bowel diseases
T2 - are we there yet?
AU - Gkikas, Konstantinos
AU - Gerasimidis, Konstantinos
AU - Milling, Simon
AU - Ijaz, Umer Z.
AU - Hansen, Richard
AU - Russell, Richard K.
N1 - Funding Information:
The studentship of K Gkikas is partly funded by Nestle Health Science. The funders had no role in the conception, design, execution, interpretation, writing or submission of this manuscript.
Publisher Copyright:
© 2020 by the authors.
PY - 2020/7/7
Y1 - 2020/7/7
N2 - The etiopathogenesis of Inflammatory bowel disease (IBD) is a result of a complex interaction between host immune response, the gut microbiome and environmental factors, such as diet. Although scientific advances, with the use of biological medications, have revolutionized IBD treatment, the challenge for maintaining clinical remission and delaying clinical relapse is still present. As exclusive enteral nutrition has become a well‐established treatment for the induction of remission in pediatric Crohn’s disease, the scientific interest regarding diet in IBD is now focused on the development of follow‐on dietary strategies, which aim to suppress colonic inflammation and delay a disease flare. The objective of this review is to present an extensive overview of the dietary strategies, which have been used in the literature to maintain clinical remission in both Crohn’s disease and Ulcerative colitis, and the evidence surrounding the association of dietary components with clinical relapse. We also aim to provide study‐related recommendations to be encompassed in future research studies aiming to investigate the role of diet during remission periods in IBD.
AB - The etiopathogenesis of Inflammatory bowel disease (IBD) is a result of a complex interaction between host immune response, the gut microbiome and environmental factors, such as diet. Although scientific advances, with the use of biological medications, have revolutionized IBD treatment, the challenge for maintaining clinical remission and delaying clinical relapse is still present. As exclusive enteral nutrition has become a well‐established treatment for the induction of remission in pediatric Crohn’s disease, the scientific interest regarding diet in IBD is now focused on the development of follow‐on dietary strategies, which aim to suppress colonic inflammation and delay a disease flare. The objective of this review is to present an extensive overview of the dietary strategies, which have been used in the literature to maintain clinical remission in both Crohn’s disease and Ulcerative colitis, and the evidence surrounding the association of dietary components with clinical relapse. We also aim to provide study‐related recommendations to be encompassed in future research studies aiming to investigate the role of diet during remission periods in IBD.
KW - Clinical relapse
KW - Crohn’s disease
KW - Dietary therapy
KW - Dietary triggers
KW - Inflammatory bowel disease
KW - Maintenance enteral nutrition
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85087824732&partnerID=8YFLogxK
U2 - 10.3390/nu12072018
DO - 10.3390/nu12072018
M3 - Review article
C2 - 32645980
SN - 2072-6643
VL - 12
JO - Nutrients
JF - Nutrients
IS - 7
M1 - 2018
ER -