TY - JOUR
T1 - Dietary treatment of Crohn's disease
T2 - perceptions of families with children treated by exclusive enteral nutrition, a questionnaire survey
AU - Svolos, Vaios
AU - Gerasimidis, Konstantinos
AU - Buchanan, Elaine
AU - Curtis, Lee
AU - Garrick, Vikki
AU - Hay, Jacqueline
AU - Laird, Susan
AU - Munro, Joanna
AU - Gaya, Daniel R.
AU - Russell, Richard K.
AU - Hansen, Richard
N1 - Funding Information:
RH, RKR and DRG are supported by NHS Research Scotland Career Researcher Fellowships. KG has received speaker’s fees, travel support and research grants from Nutricia and/or Nestle. RKR has received speaker’s fees, travel support, and/or participated in medical board meetings with Nestle, MSD Immunology, AbbVie, Dr Falk, Takeda, Napp, Mead Johnson, Nutricia & 4D Pharma. DRG has received honoraria for educational meetings from MSD, AbbVie, Takeda & Ferring. RH has received speaker’s fees, travel support, and/ or participated in medical board meetings with MSD Immunology, Dr Falk, Nutricia & 4D Pharma.
Funding Information:
The authors are supported by the Glasgow Children’s Hospital Charity and the Catherine McEwan Foundation.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/1/19
Y1 - 2017/1/19
N2 - Background: Diet is strongly associated with the aetiology of Crohn's Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of EEN and alternative novel, solid food-based diets (SFDs) expressed by paediatric patients with CD, previously treated with EEN and their parents. Methods: This anonymous questionnaire surveyed families of CD patients treated with EEN over 1 year. Two questionnaire forms were completed; one asking the patients' opinions and another referring to their main carer. This questionnaire explored participants' demographic characteristics; acceptability of a repeat EEN course to treat a future flare (EEN repeat); their opinion on how difficult EEN would be compared to an example SFD; and their intention to participate in a future clinical trial assessing the therapeutic efficacy of an SFD in CD. Results: Forty-one families of CD patients were approached with 29 sending replies (71%). Most of our participants were positive on completing another EEN course, however the majority would choose an SFD alternative (Patients:66, Parents:72%). Both patients and their parents rated EEN to be more difficult to adhere to compared to an example SFD (p < 0.05), and their ratings were strongly correlated (EEN:r = 0.83, SFD:r = 0.75, p < 0.001). The majority of our respondents would agree to participate in a clinical trial assessing an SFD's effectiveness (Patients:79, Parents:72%) for the management of active CD.Conclusions: While patients with CD and their families would accept an EEN repeat, the majority would prefer an SFD alternative. CD families surveyed are supportive of the development of solid food-based dietary treatments.
AB - Background: Diet is strongly associated with the aetiology of Crohn's Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of EEN and alternative novel, solid food-based diets (SFDs) expressed by paediatric patients with CD, previously treated with EEN and their parents. Methods: This anonymous questionnaire surveyed families of CD patients treated with EEN over 1 year. Two questionnaire forms were completed; one asking the patients' opinions and another referring to their main carer. This questionnaire explored participants' demographic characteristics; acceptability of a repeat EEN course to treat a future flare (EEN repeat); their opinion on how difficult EEN would be compared to an example SFD; and their intention to participate in a future clinical trial assessing the therapeutic efficacy of an SFD in CD. Results: Forty-one families of CD patients were approached with 29 sending replies (71%). Most of our participants were positive on completing another EEN course, however the majority would choose an SFD alternative (Patients:66, Parents:72%). Both patients and their parents rated EEN to be more difficult to adhere to compared to an example SFD (p < 0.05), and their ratings were strongly correlated (EEN:r = 0.83, SFD:r = 0.75, p < 0.001). The majority of our respondents would agree to participate in a clinical trial assessing an SFD's effectiveness (Patients:79, Parents:72%) for the management of active CD.Conclusions: While patients with CD and their families would accept an EEN repeat, the majority would prefer an SFD alternative. CD families surveyed are supportive of the development of solid food-based dietary treatments.
KW - Crohn's disease
KW - Diet
KW - Dietary therapy
KW - Exclusive enteral nutrition
KW - Perceptions
UR - http://www.scopus.com/inward/record.url?scp=85009963260&partnerID=8YFLogxK
U2 - 10.1186/s12876-016-0564-7
DO - 10.1186/s12876-016-0564-7
M3 - Article
C2 - 28103809
AN - SCOPUS:85009963260
SN - 1471-230X
VL - 17
JO - BMC Gastroenterology
JF - BMC Gastroenterology
IS - 1
M1 - 14 (2017)
ER -