Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates

Jiraporn Jaroenpool, Kenneth A. Rogers, Kovit Pattanapanyasat, Francois Villinger, Nattawat Onlamoon, Paul R. Crocker, Aftab A. Ansari

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    The expression of the Siglec family of molecules by hematopoietic cells from uninfected and SIV infected disease susceptible rhesus macaques (RM) and SIV infected disease resistant sooty mangabeys (SM) and for comparison humans was carried out. The predominant cell lineage in all three species expressing Siglec's was monocytes. The major finding by both a cross sectional and a prospective SIV infection study showed that, whereas monocytes from RM show marked increase in each Siglec constitutively expressed, monocytes from SM showed marked decreases in Siglec-1 expression. While monocytes from all three species constitutively expressed Siglec-3, human monocytes in addition expressed Siglec-5 and -9 and to a lower density 7, monocytes from RM expressed Siglec-7 and those from SM expressed Siglec-1. Monocytes from all three species, however, expressed mRNA for Siglec-1, -5, -7 and -9. The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed. (c) 2008 Elsevier Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)91-104
    Number of pages14
    JournalCellular Immunology
    Volume250
    Issue number1-2
    DOIs
    Publication statusPublished - Nov 2007

    Keywords

    • Siglec
    • Non-human primate
    • SIV infection
    • Monocytes
    • Hematopoietic cell lineages
    • Acid-binding receptor
    • Plasmacytoid dendritic cells
    • Natural killer cells
    • Sooty mangabeys
    • Immunoglobulin superfamily
    • CD33-related siglecs
    • Immune activation
    • Innate immunity
    • Up regulation
    • T-cells

    Cite this

    Jaroenpool, Jiraporn ; Rogers, Kenneth A. ; Pattanapanyasat, Kovit ; Villinger, Francois ; Onlamoon, Nattawat ; Crocker, Paul R. ; Ansari, Aftab A. / Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. In: Cellular Immunology. 2007 ; Vol. 250, No. 1-2. pp. 91-104.
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    abstract = "The expression of the Siglec family of molecules by hematopoietic cells from uninfected and SIV infected disease susceptible rhesus macaques (RM) and SIV infected disease resistant sooty mangabeys (SM) and for comparison humans was carried out. The predominant cell lineage in all three species expressing Siglec's was monocytes. The major finding by both a cross sectional and a prospective SIV infection study showed that, whereas monocytes from RM show marked increase in each Siglec constitutively expressed, monocytes from SM showed marked decreases in Siglec-1 expression. While monocytes from all three species constitutively expressed Siglec-3, human monocytes in addition expressed Siglec-5 and -9 and to a lower density 7, monocytes from RM expressed Siglec-7 and those from SM expressed Siglec-1. Monocytes from all three species, however, expressed mRNA for Siglec-1, -5, -7 and -9. The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed. (c) 2008 Elsevier Inc. All rights reserved.",
    keywords = "Siglec, Non-human primate, SIV infection, Monocytes, Hematopoietic cell lineages, Acid-binding receptor, Plasmacytoid dendritic cells, Natural killer cells, Sooty mangabeys, Immunoglobulin superfamily, CD33-related siglecs, Immune activation, Innate immunity, Up regulation, T-cells",
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    Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. / Jaroenpool, Jiraporn; Rogers, Kenneth A.; Pattanapanyasat, Kovit; Villinger, Francois; Onlamoon, Nattawat; Crocker, Paul R.; Ansari, Aftab A.

    In: Cellular Immunology, Vol. 250, No. 1-2, 11.2007, p. 91-104.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates

    AU - Jaroenpool, Jiraporn

    AU - Rogers, Kenneth A.

    AU - Pattanapanyasat, Kovit

    AU - Villinger, Francois

    AU - Onlamoon, Nattawat

    AU - Crocker, Paul R.

    AU - Ansari, Aftab A.

    PY - 2007/11

    Y1 - 2007/11

    N2 - The expression of the Siglec family of molecules by hematopoietic cells from uninfected and SIV infected disease susceptible rhesus macaques (RM) and SIV infected disease resistant sooty mangabeys (SM) and for comparison humans was carried out. The predominant cell lineage in all three species expressing Siglec's was monocytes. The major finding by both a cross sectional and a prospective SIV infection study showed that, whereas monocytes from RM show marked increase in each Siglec constitutively expressed, monocytes from SM showed marked decreases in Siglec-1 expression. While monocytes from all three species constitutively expressed Siglec-3, human monocytes in addition expressed Siglec-5 and -9 and to a lower density 7, monocytes from RM expressed Siglec-7 and those from SM expressed Siglec-1. Monocytes from all three species, however, expressed mRNA for Siglec-1, -5, -7 and -9. The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed. (c) 2008 Elsevier Inc. All rights reserved.

    AB - The expression of the Siglec family of molecules by hematopoietic cells from uninfected and SIV infected disease susceptible rhesus macaques (RM) and SIV infected disease resistant sooty mangabeys (SM) and for comparison humans was carried out. The predominant cell lineage in all three species expressing Siglec's was monocytes. The major finding by both a cross sectional and a prospective SIV infection study showed that, whereas monocytes from RM show marked increase in each Siglec constitutively expressed, monocytes from SM showed marked decreases in Siglec-1 expression. While monocytes from all three species constitutively expressed Siglec-3, human monocytes in addition expressed Siglec-5 and -9 and to a lower density 7, monocytes from RM expressed Siglec-7 and those from SM expressed Siglec-1. Monocytes from all three species, however, expressed mRNA for Siglec-1, -5, -7 and -9. The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed. (c) 2008 Elsevier Inc. All rights reserved.

    KW - Siglec

    KW - Non-human primate

    KW - SIV infection

    KW - Monocytes

    KW - Hematopoietic cell lineages

    KW - Acid-binding receptor

    KW - Plasmacytoid dendritic cells

    KW - Natural killer cells

    KW - Sooty mangabeys

    KW - Immunoglobulin superfamily

    KW - CD33-related siglecs

    KW - Immune activation

    KW - Innate immunity

    KW - Up regulation

    KW - T-cells

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    ER -