Different factors influence recanalisation rate after coiling in ruptured and unruptured intracranial aneurysms

Iris Q Grunwald; Joyce S Balami; Daniela Weber; Jessica Mutter; Anna L Kühn; Christoph Krick; Wolfgang Reith; Panagiotis Papanagiotou; Kaveh Shariat

doi:10.2174/18715273112119990055

Different factors influence recanalisation rate after coiling in ruptured and unruptured intracranial aneurysms

Iris Q Grunwald (Lead / Corresponding author), Joyce S Balami, Daniela Weber, Jessica Mutter, Anna L Kühn, Christoph Krick, Wolfgang Reith, Panagiotis Papanagiotou, Kaveh Shariat

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background: Most studies evaluating long-term efficacy after coil embolisation of intracranial aneurysms have not differentiated between ruptured and unruptured aneurysms.

Objectives: The aim of this study was to analyse factors that influence recanalisation in ruptured and unruptured aneurysms.

Methods: We performed a retrospective analysis of 182 (98 ruptured, 84 unruptured) aneurysms, treated with coil embolisation alone that received follow-up with digital substraction angiography (DSA).

Results: At 6 months 26% of the aneurysms showed recanalisation. Multivariate variance analysis revealed that different factors influenced recanalisation in ruptured and unruptured aneurysms. In ruptured aneurysms patient age was a determinant, with younger patients recanalising more frequently than older ones (p = 0.016). Also, low initial packing density led to higher recanalisation rates (p = 0.015) than higher packing. In the unruptured aneurysm group these factors were not significant. Here, only a larger aneurysm volume led to higher recanalisation rates (p = 0.027).

Conclusions: Our data suggest that in ruptured aneurysms, high packing density is a key factor to prevent recanalisation, while in unruptured aneurysms, aneurysm volume is the main predictor for recanalisation.

Original language	English
Pages (from-to)	228-232
Number of pages	5
Journal	CNS & neurological disorders drug targets
Volume	12
Issue number	2
DOIs	https://doi.org/10.2174/18715273112119990055
Publication status	Published - Mar 2013

Keywords

Aneurysm, Ruptured/surgery
Angiography, Digital Subtraction
Embolization, Therapeutic/instrumentation
Female
Humans
Intracranial Aneurysm/surgery
Longitudinal Studies
Male
Middle Aged
Retrospective Studies
Statistics, Nonparametric
Surgical Instruments
Treatment Outcome

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10.2174/18715273112119990055

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title = "Different factors influence recanalisation rate after coiling in ruptured and unruptured intracranial aneurysms",

abstract = "Background: Most studies evaluating long-term efficacy after coil embolisation of intracranial aneurysms have not differentiated between ruptured and unruptured aneurysms. Objectives: The aim of this study was to analyse factors that influence recanalisation in ruptured and unruptured aneurysms.Methods: We performed a retrospective analysis of 182 (98 ruptured, 84 unruptured) aneurysms, treated with coil embolisation alone that received follow-up with digital substraction angiography (DSA). Results: At 6 months 26% of the aneurysms showed recanalisation. Multivariate variance analysis revealed that different factors influenced recanalisation in ruptured and unruptured aneurysms. In ruptured aneurysms patient age was a determinant, with younger patients recanalising more frequently than older ones (p = 0.016). Also, low initial packing density led to higher recanalisation rates (p = 0.015) than higher packing. In the unruptured aneurysm group these factors were not significant. Here, only a larger aneurysm volume led to higher recanalisation rates (p = 0.027). Conclusions: Our data suggest that in ruptured aneurysms, high packing density is a key factor to prevent recanalisation, while in unruptured aneurysms, aneurysm volume is the main predictor for recanalisation.",

keywords = "Aneurysm, Ruptured/surgery, Angiography, Digital Subtraction, Embolization, Therapeutic/instrumentation, Female, Humans, Intracranial Aneurysm/surgery, Longitudinal Studies, Male, Middle Aged, Retrospective Studies, Statistics, Nonparametric, Surgical Instruments, Treatment Outcome",

author = "Grunwald, {Iris Q} and Balami, {Joyce S} and Daniela Weber and Jessica Mutter and K{\"u}hn, {Anna L} and Christoph Krick and Wolfgang Reith and Panagiotis Papanagiotou and Kaveh Shariat",

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doi = "10.2174/18715273112119990055",

language = "English",

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T1 - Different factors influence recanalisation rate after coiling in ruptured and unruptured intracranial aneurysms

AU - Grunwald, Iris Q

AU - Balami, Joyce S

AU - Weber, Daniela

AU - Mutter, Jessica

AU - Kühn, Anna L

AU - Krick, Christoph

AU - Reith, Wolfgang

AU - Papanagiotou, Panagiotis

AU - Shariat, Kaveh

PY - 2013/3

Y1 - 2013/3

N2 - Background: Most studies evaluating long-term efficacy after coil embolisation of intracranial aneurysms have not differentiated between ruptured and unruptured aneurysms. Objectives: The aim of this study was to analyse factors that influence recanalisation in ruptured and unruptured aneurysms.Methods: We performed a retrospective analysis of 182 (98 ruptured, 84 unruptured) aneurysms, treated with coil embolisation alone that received follow-up with digital substraction angiography (DSA). Results: At 6 months 26% of the aneurysms showed recanalisation. Multivariate variance analysis revealed that different factors influenced recanalisation in ruptured and unruptured aneurysms. In ruptured aneurysms patient age was a determinant, with younger patients recanalising more frequently than older ones (p = 0.016). Also, low initial packing density led to higher recanalisation rates (p = 0.015) than higher packing. In the unruptured aneurysm group these factors were not significant. Here, only a larger aneurysm volume led to higher recanalisation rates (p = 0.027). Conclusions: Our data suggest that in ruptured aneurysms, high packing density is a key factor to prevent recanalisation, while in unruptured aneurysms, aneurysm volume is the main predictor for recanalisation.

AB - Background: Most studies evaluating long-term efficacy after coil embolisation of intracranial aneurysms have not differentiated between ruptured and unruptured aneurysms. Objectives: The aim of this study was to analyse factors that influence recanalisation in ruptured and unruptured aneurysms.Methods: We performed a retrospective analysis of 182 (98 ruptured, 84 unruptured) aneurysms, treated with coil embolisation alone that received follow-up with digital substraction angiography (DSA). Results: At 6 months 26% of the aneurysms showed recanalisation. Multivariate variance analysis revealed that different factors influenced recanalisation in ruptured and unruptured aneurysms. In ruptured aneurysms patient age was a determinant, with younger patients recanalising more frequently than older ones (p = 0.016). Also, low initial packing density led to higher recanalisation rates (p = 0.015) than higher packing. In the unruptured aneurysm group these factors were not significant. Here, only a larger aneurysm volume led to higher recanalisation rates (p = 0.027). Conclusions: Our data suggest that in ruptured aneurysms, high packing density is a key factor to prevent recanalisation, while in unruptured aneurysms, aneurysm volume is the main predictor for recanalisation.

KW - Aneurysm, Ruptured/surgery

KW - Angiography, Digital Subtraction

KW - Embolization, Therapeutic/instrumentation

KW - Female

KW - Humans

KW - Intracranial Aneurysm/surgery

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Statistics, Nonparametric

KW - Surgical Instruments

KW - Treatment Outcome

U2 - 10.2174/18715273112119990055

DO - 10.2174/18715273112119990055

M3 - Article

C2 - 23394534

SN - 1871-5273

VL - 12

SP - 228

EP - 232

JO - CNS & neurological disorders drug targets

JF - CNS & neurological disorders drug targets

IS - 2

ER -

Different factors influence recanalisation rate after coiling in ruptured and unruptured intracranial aneurysms

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Keywords

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