Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma

D. Menzies, A. Nair, P. Hopkinson, L. McFarlane, B. J. Lipworth

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Extra-fine particle formulations of hydrofluoroalkane-134a beclometasone dipropionate (HFA-BDP) exhibit clinical effects comparable with conventional particle formulations of chlorofluorocarbon beclometasone dipropionate (CFC-BDP) at half the dose. There is little data comparing their effects on inflammation. We have evaluated the effects of HFA-BDP and CFC-BDP on pulmonary and systemic markers of asthmatic inflammation.
    Original languageEnglish
    Pages (from-to)661-667
    Number of pages7
    JournalAllergy
    Volume62
    Issue number6
    DOIs
    Publication statusPublished - Jun 2007

    Keywords

    • Acetates
    • Administration, Inhalation
    • Adrenal Cortex Hormones
    • Anti-Asthmatic Agents
    • Anti-Inflammatory Agents
    • Asthma
    • Beclomethasone
    • Chemistry, Pharmaceutical
    • Chlorofluorocarbons
    • Dose-Response Relationship, Drug
    • Double-Blind Method
    • Drug Therapy, Combination
    • Eosinophils
    • Humans
    • Hydrocarbons, Fluorinated
    • Inflammation
    • Nitric Oxide
    • Particle Size
    • Quinolines

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