Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma

D. Menzies; A. Nair; P. Hopkinson; L. McFarlane; B. J. Lipworth

doi:10.1111/j.1398-9995.2007.01376.x

Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma

D. Menzies, A. Nair, P. Hopkinson, L. McFarlane, B. J. Lipworth

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Extra-fine particle formulations of hydrofluoroalkane-134a beclometasone dipropionate (HFA-BDP) exhibit clinical effects comparable with conventional particle formulations of chlorofluorocarbon beclometasone dipropionate (CFC-BDP) at half the dose. There is little data comparing their effects on inflammation. We have evaluated the effects of HFA-BDP and CFC-BDP on pulmonary and systemic markers of asthmatic inflammation.

Original language	English
Pages (from-to)	661-667
Number of pages	7
Journal	Allergy
Volume	62
Issue number	6
DOIs	https://doi.org/10.1111/j.1398-9995.2007.01376.x
Publication status	Published - Jun 2007

Keywords

Acetates
Administration, Inhalation
Adrenal Cortex Hormones
Anti-Asthmatic Agents
Anti-Inflammatory Agents
Asthma
Beclomethasone
Chemistry, Pharmaceutical
Chlorofluorocarbons
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Eosinophils
Humans
Hydrocarbons, Fluorinated
Inflammation
Nitric Oxide
Particle Size
Quinolines

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10.1111/j.1398-9995.2007.01376.x

http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291398-9995

Cite this

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title = "Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma",

abstract = "Extra-fine particle formulations of hydrofluoroalkane-134a beclometasone dipropionate (HFA-BDP) exhibit clinical effects comparable with conventional particle formulations of chlorofluorocarbon beclometasone dipropionate (CFC-BDP) at half the dose. There is little data comparing their effects on inflammation. We have evaluated the effects of HFA-BDP and CFC-BDP on pulmonary and systemic markers of asthmatic inflammation.",

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author = "D. Menzies and A. Nair and P. Hopkinson and L. McFarlane and Lipworth, {B. J.}",

year = "2007",

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T1 - Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma

AU - Menzies, D.

AU - Nair, A.

AU - Hopkinson, P.

AU - McFarlane, L.

AU - Lipworth, B. J.

PY - 2007/6

Y1 - 2007/6

N2 - Extra-fine particle formulations of hydrofluoroalkane-134a beclometasone dipropionate (HFA-BDP) exhibit clinical effects comparable with conventional particle formulations of chlorofluorocarbon beclometasone dipropionate (CFC-BDP) at half the dose. There is little data comparing their effects on inflammation. We have evaluated the effects of HFA-BDP and CFC-BDP on pulmonary and systemic markers of asthmatic inflammation.

AB - Extra-fine particle formulations of hydrofluoroalkane-134a beclometasone dipropionate (HFA-BDP) exhibit clinical effects comparable with conventional particle formulations of chlorofluorocarbon beclometasone dipropionate (CFC-BDP) at half the dose. There is little data comparing their effects on inflammation. We have evaluated the effects of HFA-BDP and CFC-BDP on pulmonary and systemic markers of asthmatic inflammation.

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KW - Administration, Inhalation

KW - Adrenal Cortex Hormones

KW - Anti-Asthmatic Agents

KW - Anti-Inflammatory Agents

KW - Asthma

KW - Beclomethasone

KW - Chemistry, Pharmaceutical

KW - Chlorofluorocarbons

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Eosinophils

KW - Humans

KW - Hydrocarbons, Fluorinated

KW - Inflammation

KW - Nitric Oxide

KW - Particle Size

KW - Quinolines

U2 - 10.1111/j.1398-9995.2007.01376.x

DO - 10.1111/j.1398-9995.2007.01376.x

M3 - Article

C2 - 17508971

SN - 0105-4538

VL - 62

SP - 661

EP - 667

JO - Allergy

JF - Allergy

IS - 6

ER -

Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma

Abstract

Keywords

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