Differential cell cycle regulation by low- and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix

Shirley A. Southern; C. Simon Herrington

Differential cell cycle regulation by low- and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix

Shirley A. Southern
, C. Simon Herrington

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we have demonstrated the overexpression of cyclin D1 protein in 24 (92%) of 26 low-grade squamous intraepithelial lesions infected with low-risk human papillomaviruses (HPV 6, Il, 42, 43, and.44) and the absence of cyclin D1 expression in 25 (87%) of 29 lesions infected with high-risk HPVs (HPV 16, 18, 31, 33, 39, IJ, 51, 52, 56, 58, and 66), The expression of cyclins E, A, and B proteins was increased in both low-risk and high-risk HPV infections. Tetrasomy of chromosomes 1, 3, 11, 17, 18, and X was present in nine lesions, all of which were infected with high-risk HPVs, but was not related to the pattern of cyclin expression. These data provide irt vivo evidence that low- and high-risk HPV types alter cell cycle control by different mechanisms and that cell cycle checkpoint abnormalities are induced by high-risk, but not low-risk, HPV infection.

Original language	English
Pages (from-to)	2941-2945
Number of pages	5
Journal	Cancer Research
Volume	58
Issue number	14
Publication status	Published - 1998

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Cite this

@article{be660775b44b4a219af8599ee750551f,

title = "Differential cell cycle regulation by low- and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix",

abstract = "In this study, we have demonstrated the overexpression of cyclin D1 protein in 24 (92\%) of 26 low-grade squamous intraepithelial lesions infected with low-risk human papillomaviruses (HPV 6, Il, 42, 43, and.44) and the absence of cyclin D1 expression in 25 (87\%) of 29 lesions infected with high-risk HPVs (HPV 16, 18, 31, 33, 39, IJ, 51, 52, 56, 58, and 66), The expression of cyclins E, A, and B proteins was increased in both low-risk and high-risk HPV infections. Tetrasomy of chromosomes 1, 3, 11, 17, 18, and X was present in nine lesions, all of which were infected with high-risk HPVs, but was not related to the pattern of cyclin expression. These data provide irt vivo evidence that low- and high-risk HPV types alter cell cycle control by different mechanisms and that cell cycle checkpoint abnormalities are induced by high-risk, but not low-risk, HPV infection.",

author = "Southern, \{Shirley A.\} and Herrington, \{C. Simon\}",

note = "Supported by grants from Wellbeing and the Royal College of Obstetricians and Gynecologists (H1/96) and the University of Liverpool",

year = "1998",

language = "English",

volume = "58",

pages = "2941--2945",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "14",

}

TY - JOUR

T1 - Differential cell cycle regulation by low- and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix

AU - Southern, Shirley A.

AU - Herrington, C. Simon

N1 - Supported by grants from Wellbeing and the Royal College of Obstetricians and Gynecologists (H1/96) and the University of Liverpool

PY - 1998

Y1 - 1998

N2 - In this study, we have demonstrated the overexpression of cyclin D1 protein in 24 (92%) of 26 low-grade squamous intraepithelial lesions infected with low-risk human papillomaviruses (HPV 6, Il, 42, 43, and.44) and the absence of cyclin D1 expression in 25 (87%) of 29 lesions infected with high-risk HPVs (HPV 16, 18, 31, 33, 39, IJ, 51, 52, 56, 58, and 66), The expression of cyclins E, A, and B proteins was increased in both low-risk and high-risk HPV infections. Tetrasomy of chromosomes 1, 3, 11, 17, 18, and X was present in nine lesions, all of which were infected with high-risk HPVs, but was not related to the pattern of cyclin expression. These data provide irt vivo evidence that low- and high-risk HPV types alter cell cycle control by different mechanisms and that cell cycle checkpoint abnormalities are induced by high-risk, but not low-risk, HPV infection.

AB - In this study, we have demonstrated the overexpression of cyclin D1 protein in 24 (92%) of 26 low-grade squamous intraepithelial lesions infected with low-risk human papillomaviruses (HPV 6, Il, 42, 43, and.44) and the absence of cyclin D1 expression in 25 (87%) of 29 lesions infected with high-risk HPVs (HPV 16, 18, 31, 33, 39, IJ, 51, 52, 56, 58, and 66), The expression of cyclins E, A, and B proteins was increased in both low-risk and high-risk HPV infections. Tetrasomy of chromosomes 1, 3, 11, 17, 18, and X was present in nine lesions, all of which were infected with high-risk HPVs, but was not related to the pattern of cyclin expression. These data provide irt vivo evidence that low- and high-risk HPV types alter cell cycle control by different mechanisms and that cell cycle checkpoint abnormalities are induced by high-risk, but not low-risk, HPV infection.

M3 - Article

SN - 0008-5472

VL - 58

SP - 2941

EP - 2945

JO - Cancer Research

JF - Cancer Research

IS - 14

ER -

Differential cell cycle regulation by low- and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix

Abstract

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