Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.
- Tumor Suppressor Protein p53
- DNA Damage
- Oxidative Stress
- Cyclin-Dependent Kinase Inhibitor p21
- PUVA Therapy
- Aminolevulinic Acid
Finlan, L. E., Kernohan, N. M., Thomson, G., Beattie, P. E., Hupp, T. R., & Ibbotson, S. H. (2005). Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo. The British journal of dermatology, 153(5), 1001-1010. https://doi.org/10.1111/j.1365-2133.2005.06922.x