Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

L. E. Finlan, N. M. Kernohan, G. Thomson, P. E. Beattie, T. R. Hupp, S. H. Ibbotson

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.
    Original languageEnglish
    Pages (from-to)1001-1010
    Number of pages10
    JournalThe British journal of dermatology
    Volume153
    Issue number5
    DOIs
    Publication statusPublished - Nov 2005

    Fingerprint

    PUVA Therapy
    Aminolevulinic Acid
    Photochemotherapy
    Phosphorylation
    Skin
    Skin Neoplasms
    Animal Models
    Neoplasms
    Proteins

    Keywords

    • Tumor Suppressor Protein p53
    • Skin
    • Apoptosis
    • Phosphorylation
    • DNA Damage
    • Humans
    • Photochemotherapy
    • Oxidative Stress
    • Cyclin-Dependent Kinase Inhibitor p21
    • PUVA Therapy
    • Keratinocytes
    • Aminolevulinic Acid

    Cite this

    @article{36950768cf7042e29564041643c7df83,
    title = "Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo",
    abstract = "Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.",
    keywords = "Tumor Suppressor Protein p53, Skin, Apoptosis, Phosphorylation, DNA Damage, Humans, Photochemotherapy, Oxidative Stress, Cyclin-Dependent Kinase Inhibitor p21, PUVA Therapy, Keratinocytes, Aminolevulinic Acid",
    author = "Finlan, {L. E.} and Kernohan, {N. M.} and G. Thomson and Beattie, {P. E.} and Hupp, {T. R.} and Ibbotson, {S. H.}",
    year = "2005",
    month = "11",
    doi = "10.1111/j.1365-2133.2005.06922.x",
    language = "English",
    volume = "153",
    pages = "1001--1010",
    journal = "British Journal of Dermatology",
    issn = "0007-0963",
    publisher = "Wiley",
    number = "5",

    }

    Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo. / Finlan, L. E.; Kernohan, N. M.; Thomson, G.; Beattie, P. E.; Hupp, T. R.; Ibbotson, S. H.

    In: The British journal of dermatology, Vol. 153, No. 5, 11.2005, p. 1001-1010.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

    AU - Finlan, L. E.

    AU - Kernohan, N. M.

    AU - Thomson, G.

    AU - Beattie, P. E.

    AU - Hupp, T. R.

    AU - Ibbotson, S. H.

    PY - 2005/11

    Y1 - 2005/11

    N2 - Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.

    AB - Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.

    KW - Tumor Suppressor Protein p53

    KW - Skin

    KW - Apoptosis

    KW - Phosphorylation

    KW - DNA Damage

    KW - Humans

    KW - Photochemotherapy

    KW - Oxidative Stress

    KW - Cyclin-Dependent Kinase Inhibitor p21

    KW - PUVA Therapy

    KW - Keratinocytes

    KW - Aminolevulinic Acid

    U2 - 10.1111/j.1365-2133.2005.06922.x

    DO - 10.1111/j.1365-2133.2005.06922.x

    M3 - Article

    VL - 153

    SP - 1001

    EP - 1010

    JO - British Journal of Dermatology

    JF - British Journal of Dermatology

    SN - 0007-0963

    IS - 5

    ER -