Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

L. E. Finlan, N. M. Kernohan, G. Thomson, P. E. Beattie, T. R. Hupp, S. H. Ibbotson

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    Abstract

    Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.
    Original languageEnglish
    Pages (from-to)1001-1010
    Number of pages10
    JournalThe British journal of dermatology
    Volume153
    Issue number5
    DOIs
    Publication statusPublished - Nov 2005

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    Keywords

    • Tumor Suppressor Protein p53
    • Skin
    • Apoptosis
    • Phosphorylation
    • DNA Damage
    • Humans
    • Photochemotherapy
    • Oxidative Stress
    • Cyclin-Dependent Kinase Inhibitor p21
    • PUVA Therapy
    • Keratinocytes
    • Aminolevulinic Acid

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