Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

L. E. Finlan; N. M. Kernohan; G. Thomson; P. E. Beattie; T. R. Hupp; S. H. Ibbotson

doi:10.1111/j.1365-2133.2005.06922.x

Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

L. E. Finlan, N. M. Kernohan, G. Thomson, P. E. Beattie, T. R. Hupp, S. H. Ibbotson

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.

Original language	English
Pages (from-to)	1001-1010
Number of pages	10
Journal	The British journal of dermatology
Volume	153
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2133.2005.06922.x
Publication status	Published - Nov 2005

Keywords

Tumor Suppressor Protein p53
Skin
Apoptosis
Phosphorylation
DNA Damage
Humans
Photochemotherapy
Oxidative Stress
Cyclin-Dependent Kinase Inhibitor p21
PUVA Therapy
Keratinocytes
Aminolevulinic Acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2133.2005.06922.x

http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291365-2133

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@article{36950768cf7042e29564041643c7df83,

title = "Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo",

abstract = "Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.",

keywords = "Tumor Suppressor Protein p53, Skin, Apoptosis, Phosphorylation, DNA Damage, Humans, Photochemotherapy, Oxidative Stress, Cyclin-Dependent Kinase Inhibitor p21, PUVA Therapy, Keratinocytes, Aminolevulinic Acid",

author = "Finlan, {L. E.} and Kernohan, {N. M.} and G. Thomson and Beattie, {P. E.} and Hupp, {T. R.} and Ibbotson, {S. H.}",

year = "2005",

month = nov,

doi = "10.1111/j.1365-2133.2005.06922.x",

language = "English",

volume = "153",

pages = "1001--1010",

journal = "The British journal of dermatology",

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T1 - Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

AU - Finlan, L. E.

AU - Kernohan, N. M.

AU - Thomson, G.

AU - Beattie, P. E.

AU - Hupp, T. R.

AU - Ibbotson, S. H.

PY - 2005/11

Y1 - 2005/11

N2 - Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.

AB - Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.

KW - Tumor Suppressor Protein p53

KW - Skin

KW - Apoptosis

KW - Phosphorylation

KW - DNA Damage

KW - Humans

KW - Photochemotherapy

KW - Oxidative Stress

KW - Cyclin-Dependent Kinase Inhibitor p21

KW - PUVA Therapy

KW - Keratinocytes

KW - Aminolevulinic Acid

U2 - 10.1111/j.1365-2133.2005.06922.x

DO - 10.1111/j.1365-2133.2005.06922.x

M3 - Article

C2 - 16225614

SN - 0007-0963

VL - 153

SP - 1001

EP - 1010

JO - The British journal of dermatology

JF - The British journal of dermatology

IS - 5

ER -

Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

Abstract

Keywords

UN SDGs

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