Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans

Rahmatina B. Herman, Peter J. Jesudason, Ali M. Mustafa, Ruby Husain, Anna Maria J. Choy, Chim C. Lang

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Evidence of long-term beneficial effects of ß-blockers on mortality and morbidity in patients with heart failure has been demonstrated in recent randomized trials. However, not all ß-blockers are identical. Carvedilol, a nonselective ß- and a-adrenergic blocker, can potentially blunt the release of noradrenaline by blocking presynaptic ß2-adrenergic receptors. To test this hypothesis, we have compared the effects of carvedilol and atenolol on plasma noradrenaline during exercise in healthy young volunteers.

    Original languageEnglish
    Pages (from-to)134-138
    Number of pages5
    JournalBritish Journal of Clinical Pharmacology
    Volume55
    Issue number2
    DOIs
    Publication statusPublished - 2003

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