Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans

Rahmatina B. Herman, Peter J. Jesudason, Ali M. Mustafa, Ruby Husain, Anna Maria J. Choy, Chim C. Lang

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Evidence of long-term beneficial effects of ß-blockers on mortality and morbidity in patients with heart failure has been demonstrated in recent randomized trials. However, not all ß-blockers are identical. Carvedilol, a nonselective ß- and a-adrenergic blocker, can potentially blunt the release of noradrenaline by blocking presynaptic ß2-adrenergic receptors. To test this hypothesis, we have compared the effects of carvedilol and atenolol on plasma noradrenaline during exercise in healthy young volunteers.

    Original languageEnglish
    Pages (from-to)134-138
    Number of pages5
    JournalBritish Journal of Clinical Pharmacology
    Volume55
    Issue number2
    DOIs
    Publication statusPublished - 2003

    Fingerprint

    Atenolol
    Norepinephrine
    Exercise
    Adrenergic Antagonists
    Adrenergic Receptors
    Healthy Volunteers
    Heart Failure
    Morbidity
    Mortality
    carvedilol

    Cite this

    Herman, Rahmatina B. ; Jesudason, Peter J. ; Mustafa, Ali M. ; Husain, Ruby ; Choy, Anna Maria J. ; Lang, Chim C. / Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans. In: British Journal of Clinical Pharmacology. 2003 ; Vol. 55, No. 2. pp. 134-138.
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    Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans. / Herman, Rahmatina B.; Jesudason, Peter J.; Mustafa, Ali M.; Husain, Ruby; Choy, Anna Maria J.; Lang, Chim C.

    In: British Journal of Clinical Pharmacology, Vol. 55, No. 2, 2003, p. 134-138.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans

    AU - Herman, Rahmatina B.

    AU - Jesudason, Peter J.

    AU - Mustafa, Ali M.

    AU - Husain, Ruby

    AU - Choy, Anna Maria J.

    AU - Lang, Chim C.

    PY - 2003

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    AB - Evidence of long-term beneficial effects of ß-blockers on mortality and morbidity in patients with heart failure has been demonstrated in recent randomized trials. However, not all ß-blockers are identical. Carvedilol, a nonselective ß- and a-adrenergic blocker, can potentially blunt the release of noradrenaline by blocking presynaptic ß2-adrenergic receptors. To test this hypothesis, we have compared the effects of carvedilol and atenolol on plasma noradrenaline during exercise in healthy young volunteers.

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    DO - 10.1046/j.1365-2125.2003.01755.x

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    JF - British Journal of Clinical Pharmacology

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