Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans

TY - JOUR

T1 - Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans

AU - Herman, Rahmatina B.

AU - Jesudason, Peter J.

AU - Mustafa, Ali M.

AU - Husain, Ruby

AU - Choy, Anna Maria J.

AU - Lang, Chim C.

PY - 2003

Y1 - 2003

N2 - Evidence of long-term beneficial effects of ß-blockers on mortality and morbidity in patients with heart failure has been demonstrated in recent randomized trials. However, not all ß-blockers are identical. Carvedilol, a nonselective ß- and a-adrenergic blocker, can potentially blunt the release of noradrenaline by blocking presynaptic ß2-adrenergic receptors. To test this hypothesis, we have compared the effects of carvedilol and atenolol on plasma noradrenaline during exercise in healthy young volunteers.

AB - Evidence of long-term beneficial effects of ß-blockers on mortality and morbidity in patients with heart failure has been demonstrated in recent randomized trials. However, not all ß-blockers are identical. Carvedilol, a nonselective ß- and a-adrenergic blocker, can potentially blunt the release of noradrenaline by blocking presynaptic ß2-adrenergic receptors. To test this hypothesis, we have compared the effects of carvedilol and atenolol on plasma noradrenaline during exercise in healthy young volunteers.

U2 - 10.1046/j.1365-2125.2003.01755.x

DO - 10.1046/j.1365-2125.2003.01755.x

M3 - Article

C2 - 12580984

SN - 0306-5251

VL - 55

SP - 134

EP - 138

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 2

ER -