Differential Expression and Regulation by Activin of the Neurotrophins BDNF and NT4 During Human and Mouse Ovarian Development

Andrew J. Childs; Rosemary A. L. Bayne; Alison A. Murray; Sarah J. Martins Da Silva; Craig S. Collins; Norah Spears; Richard A. Anderson

doi:10.1002/dvdy.22252

Differential Expression and Regulation by Activin of the Neurotrophins BDNF and NT4 During Human and Mouse Ovarian Development

Andrew J. Childs, Rosemary A. L. Bayne, Alison A. Murray, Sarah J. Martins Da Silva, Craig S. Collins, Norah Spears, Richard A. Anderson

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The tropomyosin-related kinase (Trk) B neurotrophin receptor is essential for ovarian germ cell survival and primordial follicle formation, but the contributions of its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), are unknown. We have investigated their expression and regulation in developing human and mouse ovaries. BDNF expression increased with increasing gestation, expression of human NTF4 and of both Ntf5 and Bdnf in the mouse was unchanged. Bdnf expression was dramatically lower than Ntf5 in the mouse, but levels were comparable in the human. Human fetal ovarian somatic cells expressed BDNF. Activin A selectively regulated BDNF and Ntf5 expression in human and mouse, respectively, identifying an oocyte/somatic signaling pathway which might mediate the pro-survival effects of activin. These data reveal that expression and regulation of the TrkB ligands are differentially controlled in the developing ovaries of humans and mice, and identify BDNF as a potential regulator of germ cell fate in the human fetal ovary. Developmental Dynamics 239:1211-1219, 2010. (C) 2010 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	1211-1219
Number of pages	9
Journal	Developmental Dynamics
Volume	239
Issue number	4
DOIs	https://doi.org/10.1002/dvdy.22252
Publication status	Published - Apr 2010

Keywords

neurotrophin
BDNF
NT4
ovary
oocyte
primordial follicle
activin
PRIMORDIAL FOLLICLE FORMATION
GERM-CELL SURVIVAL
HUMAN FETAL TESTIS
GENE-EXPRESSION
MAMMALIAN OVARY
RECEPTORS
NEURONS
GROWTH
MICE
FOLLICULOGENESIS

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title = "Differential Expression and Regulation by Activin of the Neurotrophins BDNF and NT4 During Human and Mouse Ovarian Development",

abstract = "The tropomyosin-related kinase (Trk) B neurotrophin receptor is essential for ovarian germ cell survival and primordial follicle formation, but the contributions of its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), are unknown. We have investigated their expression and regulation in developing human and mouse ovaries. BDNF expression increased with increasing gestation, expression of human NTF4 and of both Ntf5 and Bdnf in the mouse was unchanged. Bdnf expression was dramatically lower than Ntf5 in the mouse, but levels were comparable in the human. Human fetal ovarian somatic cells expressed BDNF. Activin A selectively regulated BDNF and Ntf5 expression in human and mouse, respectively, identifying an oocyte/somatic signaling pathway which might mediate the pro-survival effects of activin. These data reveal that expression and regulation of the TrkB ligands are differentially controlled in the developing ovaries of humans and mice, and identify BDNF as a potential regulator of germ cell fate in the human fetal ovary. Developmental Dynamics 239:1211-1219, 2010. (C) 2010 Wiley-Liss, Inc.",

keywords = "neurotrophin, BDNF, NT4, ovary, oocyte, primordial follicle, activin, PRIMORDIAL FOLLICLE FORMATION, GERM-CELL SURVIVAL, HUMAN FETAL TESTIS, GENE-EXPRESSION, MAMMALIAN OVARY, RECEPTORS, NEURONS, GROWTH, MICE, FOLLICULOGENESIS",

author = "Childs, {Andrew J.} and Bayne, {Rosemary A. L.} and Murray, {Alison A.} and {Martins Da Silva}, {Sarah J.} and Collins, {Craig S.} and Norah Spears and Anderson, {Richard A.}",

year = "2010",

month = apr,

doi = "10.1002/dvdy.22252",

language = "English",

volume = "239",

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publisher = "Wiley",

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T1 - Differential Expression and Regulation by Activin of the Neurotrophins BDNF and NT4 During Human and Mouse Ovarian Development

AU - Childs, Andrew J.

AU - Bayne, Rosemary A. L.

AU - Murray, Alison A.

AU - Martins Da Silva, Sarah J.

AU - Collins, Craig S.

AU - Spears, Norah

AU - Anderson, Richard A.

PY - 2010/4

Y1 - 2010/4

N2 - The tropomyosin-related kinase (Trk) B neurotrophin receptor is essential for ovarian germ cell survival and primordial follicle formation, but the contributions of its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), are unknown. We have investigated their expression and regulation in developing human and mouse ovaries. BDNF expression increased with increasing gestation, expression of human NTF4 and of both Ntf5 and Bdnf in the mouse was unchanged. Bdnf expression was dramatically lower than Ntf5 in the mouse, but levels were comparable in the human. Human fetal ovarian somatic cells expressed BDNF. Activin A selectively regulated BDNF and Ntf5 expression in human and mouse, respectively, identifying an oocyte/somatic signaling pathway which might mediate the pro-survival effects of activin. These data reveal that expression and regulation of the TrkB ligands are differentially controlled in the developing ovaries of humans and mice, and identify BDNF as a potential regulator of germ cell fate in the human fetal ovary. Developmental Dynamics 239:1211-1219, 2010. (C) 2010 Wiley-Liss, Inc.

AB - The tropomyosin-related kinase (Trk) B neurotrophin receptor is essential for ovarian germ cell survival and primordial follicle formation, but the contributions of its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), are unknown. We have investigated their expression and regulation in developing human and mouse ovaries. BDNF expression increased with increasing gestation, expression of human NTF4 and of both Ntf5 and Bdnf in the mouse was unchanged. Bdnf expression was dramatically lower than Ntf5 in the mouse, but levels were comparable in the human. Human fetal ovarian somatic cells expressed BDNF. Activin A selectively regulated BDNF and Ntf5 expression in human and mouse, respectively, identifying an oocyte/somatic signaling pathway which might mediate the pro-survival effects of activin. These data reveal that expression and regulation of the TrkB ligands are differentially controlled in the developing ovaries of humans and mice, and identify BDNF as a potential regulator of germ cell fate in the human fetal ovary. Developmental Dynamics 239:1211-1219, 2010. (C) 2010 Wiley-Liss, Inc.

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KW - BDNF

KW - NT4

KW - ovary

KW - oocyte

KW - primordial follicle

KW - activin

KW - PRIMORDIAL FOLLICLE FORMATION

KW - GERM-CELL SURVIVAL

KW - HUMAN FETAL TESTIS

KW - GENE-EXPRESSION

KW - MAMMALIAN OVARY

KW - RECEPTORS

KW - NEURONS

KW - GROWTH

KW - MICE

KW - FOLLICULOGENESIS

U2 - 10.1002/dvdy.22252

DO - 10.1002/dvdy.22252

M3 - Article

C2 - 20175187

SN - 1058-8388

VL - 239

SP - 1211

EP - 1219

JO - Developmental Dynamics

JF - Developmental Dynamics

IS - 4

ER -

Differential Expression and Regulation by Activin of the Neurotrophins BDNF and NT4 During Human and Mouse Ovarian Development

Abstract

Keywords

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