Differential expression of cyclin-dependent kinase inhibitors and apoptosis-related proteins in endocervical lesions

Alaa A. El-Ghobashy, Abeer M. Shaaban, Jenny Innes, Wendy Prime, C. Simon Herrington

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    The development of neoplasia is associated with abnormalities of cell cycle control and apoptosis. In this study, a panel of cyclin-dependent kinase inhibitors (CDKIs) and apoptosis-related proteins (p16, p21, p53, Bc12 and hsp27) was analysed by immunohistochernistry in 91 glandular cervical lesions. A significant increase in p21 and p53 expression occurred from normal cervix (n = 11) through endometriosis/tubo-endometrioid metaplasia (TEM) (n = 19) and cervical glandular intraepithelial neoplasia (CGIN)/adenocarcinoma in situ (AIS) (n = 33) to invasive adenocarcinoma (n = 28). p16 showed diffuse strong expression in CGIN/AIS and invasive adenocarcinoma compared with focal expression in some TEW endometriosis lesions and no expression in normal cervix. Bc12 was highly expressed in TEM/endometriosis compared with CGIN/AIS and adenocarcinoma. p16 immunostaining discriminated accurately between neoplastic and non-neoplastic cervical lesions, provided that diffuse strong positivity was present. Similarly, diffuse expression of Bc12 distinguished endometriosis/TEM from CGIN/AIS. These data demonstrate that analysis of CDKIs and apoptosis-related proteins provides useful information in the diagnostic assessment of glandular lesions of the cervix. (C) 2007 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)2011-2018
    Number of pages8
    JournalEuropean Journal of Cancer
    Issue number13
    Publication statusPublished - Sep 2007


    • Cervix
    • Glandular lesions
    • Neoplasia
    • Metaplasia
    • Cyclin-dependent kinase inhibitors
    • Apoptosis

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