Difficulties arising in reimbursement recommendations on new medicines due to inadequate reporting of population adjustment indirect comparison methods

Eileen Holmes (Lead / Corresponding author), Joy Leahy, Cathal D. Walsh, Arthur White, Peter T. Donnan, Felicity Lamrock

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
28 Downloads (Pure)

Abstract

Indirect treatment comparisons are useful to estimate relative treatment effects when head-to-head studies are not conducted. Statisticians at the National Centre for Pharmacoeconomics Ireland (NCPE) and Scottish Medicines Consortium (SMC) assess the clinical and cost-effectiveness of new medicines as part of multidisciplinary teams. We describe some shared observations on areas where reporting of population-adjustment indirect comparison methods is causing uncertainty in our recommendations to decision-making committees when assessing reimbursement of medicines.

Original languageEnglish
Pages (from-to)615-617
Number of pages3
JournalResearch Synthesis Methods
Volume10
Issue number4
Early online date27 Jun 2019
DOIs
Publication statusPublished - Dec 2019

Keywords

  • decision making
  • evidence synthesis
  • population-adjusted indirect comparisons
  • statistical models

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