Diffuse interface model for cell interaction and aggregation with Lennard-Jones type potential

Lingyue Shen, Ping Lin, Zhiliang Xu, Shixin Xu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
25 Downloads (Pure)

Abstract

This study introduces a phase-field model designed to simulate the interaction and aggregation of multicellular systems under flow conditions within a bounded spatial domain. The model incorporates a multi-dimensional Lennard-Jones potential to account for short-range repulsion and adhesive bonding between cells. To solve the governing equations while preserving energy law, a second-order accurate C0 finite element method is employed. The validity of the model is established through numerical tests, and experimental data from cell stretch tests is utilized for model calibration and validation. Additionally, the study investigates the impact of varying adhesion properties in red blood cells. Overall, this work presents a thermodynamically consistent and computationally efficient framework for simulating cell–cell and cell–wall interactions under flow conditions.

Original languageEnglish
Article number116257
Number of pages25
JournalComputer Methods in Applied Mechanics and Engineering
Volume415
Early online date25 Jul 2023
DOIs
Publication statusPublished - 1 Oct 2023

Keywords

  • Aggregation
  • Cell interaction
  • Energy-law preserving scheme

ASJC Scopus subject areas

  • Computational Mechanics
  • Mechanics of Materials
  • Mechanical Engineering
  • General Physics and Astronomy
  • Computer Science Applications

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