@article{b92fed30e3514fa78b4039d23e31bbd4,
title = "Direct and random routing of a molecular motor protein at a DNA junction",
abstract = "With the aim of investigating how motor proteins negotiate DNA nanostructures, we produced test circuits based on recombination intermediates in which 1D translocation across a Holliday junction (HJ) could be assessed by subsequent triplex displacement signals on each DNA arm. Using the EcoR124I restriction-modification enzyme, a 3′-5′ double-strand DNA (dsDNA) translocase, we could show that the motor will tend to follow its translocated strand across a junction. Nonetheless, as the frequency of junction bypass events increases, the motor will occasionally jump tracks.",
author = "Stanley, {Louise K.} and Szczelkun, {Mark D.}",
note = "Funding Information: The authors thank Dr Sean Colloms (University of Glasgow) for supplying the pJB43a plasmid and associated strains, and Prof. Malcolm White (University of St. Andrews) for supplying the Hje enzyme. This work was supported by grants from the Wellcome Trust (067439 and 071432). M.D.S. is a Wellcome Trust Senior Research Fellow in Basic Biomedical Sciences. L.K.S. is a Wellcome Trust Prize Ph.D. student. Funding to pay the Open Access publication charges for this article was provided by a Wellcome Trust {\textquoteleft}Value in People{\textquoteright} Grant to the University of Bristol, reference 078595.",
year = "2006",
month = sep,
day = "1",
doi = "10.1093/nar/gkl569",
language = "English",
volume = "34",
pages = "4387--4394",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "16",
}