Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts

Yanan Peng, Zongwei Li, Peng Yang, Ian P. Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Tumor-stroma interactions are referred to as essential events in tumor progression. There has been growing attention that bone marrow-derived mesenchymal stem cells (BMSCs) can travel to tumor stroma, where they differentiate into tumor-associated fibroblast (TAF)-like cells, a predominant tumor-promoting stromal cell. However, little is definitively known about the contributors for this transition. Here, using an in vitro direct co-culture model of colon cancer cells and BMSCs, we identify that colon cancer cells can induce adjoining BMSCs to exhibit the typical characteristic of TAFs, with increased expression of a-smooth muscle actin (a-SMA). Importantly, the present data also reveals that activated Notch signaling mediates transformation of BMSCs to TAFs through the downstream TGF-ß/Smad signaling pathway.

    Original languageEnglish
    Pages (from-to)68-73
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume451
    Issue number1
    Early online date22 Jul 2014
    DOIs
    Publication statusPublished - 15 Aug 2014

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