Direct demonstration of sulphonylurea-sensitive KATP channels on nerve terminals of the rat motor cortex

Kevin Lee, Alistair K Dixon, Iain C. M. Rowe, Michael L. J. Ashford, Peter J. Richardson

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    22 Citations (Scopus)

    Abstract

    We examined whether ATP-sensitive potassium (KATP) channels are present on presynaptic terminals of the rat motor cortex, an area of the CNS exhibiting a high density of sulphonylurea binding. A novel fused nerve terminal preparation was developed which produced structures amenable to patch clamp methods. In inside-out recordings a K+ channel was observed which possessed all the major features of the Type 1 KATP channel, including sensitivity to ATP and the antidiabetic sulphonylureas.
    Original languageEnglish
    Pages (from-to)385-7
    Number of pages3
    JournalBritish Journal of Pharmacology
    Volume115
    Issue number3
    Publication statusPublished - Jun 1995

    Keywords

    • Animals
    • Acetylcholinesterase
    • Sulfonylurea Compounds
    • Presynaptic Terminals
    • Citrate (si)-Synthase
    • Electric Stimulation
    • Potassium Channels
    • Binding Sites
    • Rats
    • Cerebral Cortex
    • L-Lactate Dehydrogenase
    • Rats, Sprague-Dawley
    • Patch-Clamp Techniques
    • Proteins
    • Nerve Endings
    • Adenosine Triphosphate
    • Choline O-Acetyltransferase
    • Male

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