Heart failure is a major health problem in western countries with high costs and poor outcome despite advances in therapy. 50% of patients die within 4 years of presentation, and 40% of patients admitted are dead or rehospitalised within 1 year. We searched for biomarkers in plasma that could predict treatment response in patients with heart failure, using bottom-up proteomics (liquid chromatography tandem mass spectrometry).
Huy, T. C., Quinn, P. A., Sandhu, J. K., Voors, A. A., Parry, H., Lang, C. C., Jones, D. J. L., & Ng, L. L. (2014). Discovering new biomarkers for predicting treatment response in heart failure using plasma proteomics. Heart (British Cardiac Society), 100 (Suppl 3), A30. https://doi.org/10.1136/heartjnl-2014-306118.52