Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain

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• Finished

  A Systems Approach for the Fragment-based Development of Selective Chemical Probes of Bromodomain Function (joint with University of Oxford)

  Ciulli, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/04/13 → 7/06/15

  Project: Research

  • Bromodomain 100%
  • Small Molecule 60%
  • Proteolysis 48%
  • Bromo 34%
  • BRD4 34%

• A Translational Engine for Biomedical Discoveries (Strategic Grant)

  Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)

  1/01/13 → 30/09/15

  Project: Research

  • Proteolysis 100%
  • Visceral Leishmaniasis 87%
  • Trypanosoma Brucei 72%
  • Ternary Complex 68%
  • Drug Discovery 65%

• State-of-the-Art Facilities for Structural Biology at the University of Dundee

  Hunter, B. (Investigator), Lilley, D. (Investigator), Owen-Hughes, T. (Investigator), Wyatt, P. (Investigator) & van Aalten, D. (Investigator)

  1/03/12 → 28/02/17

  Project: Research

  • Crystal Structure 100%
  • Enzyme 87%
  • Proteolysis 86%
  • Ternary Complex 75%
  • Ubiquitin Ligase 72%