Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

Keyphrases

• Acetyl-lysine 25%
• Binding Mode 25%
• Bromodomain 100%
• Bromodomain Inhibitors 25%
• Bromodomain-containing Protein 4 (BRD4) 75%
• Complex Structure 25%
• CREB1 75%
• Dimethyl Sulfoxide 50%
• Fragment Binding 25%
• Fragment Screening 100%
• High-resolution Crystal Structure 25%
• Key Fragment 25%
• Low Affinity 25%
• Potent Inhibitor 25%
• Primary Fragments 25%
• Screening Approach 25%
• Selective Inhibitor 25%
• Small Molecules 25%
• Surface Plasmon Resonance 25%

Biochemistry, Genetics and Molecular Biology

• BRD4 60%
• Bromodomain 100%
• Crystal Structure 20%
• Dimethyl Sulfoxide 40%
• Lysine 20%
• P300 Coactivator Associated Factor 60%
• Small Molecule 20%
• Surface Plasmon Resonance 20%