Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)

Tatsuki Koike (Lead / Corresponding author), Masato Yoshikawa, Haruhi Kamisaki Ando, William Farnaby, Toshiya Nishi, Etsurou Watanabe, Jason Yano, Maki Miyamoto, Shigeru Kondo, Tsuyoshi Ishii, Takanobu Kuroita

Biological Chemistry and Drug Discovery

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2020
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice
Nishi, T., Kondo, S., Miyamoto, M., Watanabe, S., Hasegawa, S., Kondo, S., Yano, J., Watanabe, E., Ishi, T., Yoshikawa, M., Ando, H. K., Farnaby, W., Fujimoto, S., Sunahara, E., Ohori, M., During, M. J., Kuroita, T. & Koike, T., 2020, In: Scientific Reports. 10, 10 p., 17081.
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53 Citations (Scopus)

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Discovery of soticlestat, a potent and selective inhibitor for cholesterol 24-hydroxylase (CH24H)

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Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice