Disinfection of clinical materials using photo-activated tolonium chloride solution

G. A. Thomson, M. S. Pridham, Y. L. Liu, R.E. Mackay

    Research output: Contribution to journalArticlepeer-review


    Photo-activated disinfection is beginning to be used in dental surgery to treat deep seated bacterial infection. It works by combining a photosensitiser and light of a specific frequency to generate singlet oxygen which is toxic to many types of bacteria. It is suggested that this technique could be used as a means to help treat infection more generally. To do so, it needs to work with materials and geometries exhibiting different physical and optical characteristics to teeth. In these trials, samples of stainless steel and polymethylmethacrylate were exposed to bacterial solutions of Staphylococcus aureus and Staphylococcus epidermis. These were treated with tolonium chloride-based photo-activated disinfection regimes showing positive results with typically 4 log10 reductions in colony forming units. Tests were also carried out using slotted samples to represent geometric features which might be found on implants. These tests, showed disinfectant effect however to a much lesser degree.
    Original languageEnglish
    Pages (from-to)381-393
    Number of pages13
    JournalInternational Journal of Medical Engineering and Informatics
    Issue number4
    Publication statusPublished - 2011


    • Photo-activated disinfection
    • Tolonium chloride
    • Laser
    • Staphylococcus aureus
    • Staphylococcus epidermis
    • Medical engineering
    • Clinical materials
    • Dental surgery
    • Dentists
    • Bacterial infection
    • Stainless steel
    • Polymethylmethacrylate


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