Disruption of the glutathione transferase Pi class genes

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    Abstract

    Glutathione transferases are a multi-gene family of enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates. These polymorphic enzymes, which form part of an adaptive response to chemical and oxidative stress, are widely distributed and ubiquitously expressed and are subject to regulation by a number of structurally unrelated chemicals. One of these enzymes, GST P, has been the focus of much research in recent years in relation to its involvement in the etiology of disease, particularly cancer. As part of our research efforts into GST P, we have developed a mouse line that lacks this enzyme and have used this model to investigate the consequences of the absence of GST P on tumorigenesis, drug metabolism, and toxicity.
    Original languageEnglish
    Title of host publicationGluthione transferases and gamma-glutamyl transpeptidases
    EditorsHelmut Sies, Lester Packer
    Place of PublicationSan Diego
    PublisherAcademic Press
    Pages116-135
    Number of pages20
    ISBN (Print)9780121828066
    DOIs
    Publication statusPublished - 2005

    Publication series

    NameMethods in Enzymology
    PublisherAcademic Press
    Volume401

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