Disruption of the glutathione transferase Pi class genes

Colin J.  Henderson; C. Roland  Wolf

doi:10.1016/S0076-6879(05)01007-4

Disruption of the glutathione transferase Pi class genes

Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

Abstract

Glutathione transferases are a multi-gene family of enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates. These polymorphic enzymes, which form part of an adaptive response to chemical and oxidative stress, are widely distributed and ubiquitously expressed and are subject to regulation by a number of structurally unrelated chemicals. One of these enzymes, GST P, has been the focus of much research in recent years in relation to its involvement in the etiology of disease, particularly cancer. As part of our research efforts into GST P, we have developed a mouse line that lacks this enzyme and have used this model to investigate the consequences of the absence of GST P on tumorigenesis, drug metabolism, and toxicity.

Original language	English
Title of host publication	Gluthione transferases and gamma-glutamyl transpeptidases
Editors	Helmut Sies, Lester Packer
Place of Publication	San Diego
Publisher	Academic Press
Pages	116-135
Number of pages	20
ISBN (Print)	9780121828066
DOIs	https://doi.org/10.1016/S0076-6879(05)01007-4
Publication status	Published - 2005

Publication series

Name	Methods in Enzymology
Publisher	Academic Press
Volume	401

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S0076-6879(05)01007-4

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title = "Disruption of the glutathione transferase Pi class genes",

abstract = "Glutathione transferases are a multi-gene family of enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates. These polymorphic enzymes, which form part of an adaptive response to chemical and oxidative stress, are widely distributed and ubiquitously expressed and are subject to regulation by a number of structurally unrelated chemicals. One of these enzymes, GST P, has been the focus of much research in recent years in relation to its involvement in the etiology of disease, particularly cancer. As part of our research efforts into GST P, we have developed a mouse line that lacks this enzyme and have used this model to investigate the consequences of the absence of GST P on tumorigenesis, drug metabolism, and toxicity.",

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TY - CHAP

T1 - Disruption of the glutathione transferase Pi class genes

AU - Henderson, Colin J.

AU - Wolf, C. Roland

PY - 2005

Y1 - 2005

N2 - Glutathione transferases are a multi-gene family of enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates. These polymorphic enzymes, which form part of an adaptive response to chemical and oxidative stress, are widely distributed and ubiquitously expressed and are subject to regulation by a number of structurally unrelated chemicals. One of these enzymes, GST P, has been the focus of much research in recent years in relation to its involvement in the etiology of disease, particularly cancer. As part of our research efforts into GST P, we have developed a mouse line that lacks this enzyme and have used this model to investigate the consequences of the absence of GST P on tumorigenesis, drug metabolism, and toxicity.

AB - Glutathione transferases are a multi-gene family of enzymes responsible for the metabolism of a wide range of both endogenous and exogenous substrates. These polymorphic enzymes, which form part of an adaptive response to chemical and oxidative stress, are widely distributed and ubiquitously expressed and are subject to regulation by a number of structurally unrelated chemicals. One of these enzymes, GST P, has been the focus of much research in recent years in relation to its involvement in the etiology of disease, particularly cancer. As part of our research efforts into GST P, we have developed a mouse line that lacks this enzyme and have used this model to investigate the consequences of the absence of GST P on tumorigenesis, drug metabolism, and toxicity.

U2 - 10.1016/S0076-6879(05)01007-4

DO - 10.1016/S0076-6879(05)01007-4

M3 - Other chapter contribution

SN - 9780121828066

T3 - Methods in Enzymology

SP - 116

EP - 135

BT - Gluthione transferases and gamma-glutamyl transpeptidases

A2 - Sies, Helmut

A2 - Packer, Lester

PB - Academic Press

CY - San Diego

ER -

Disruption of the glutathione transferase Pi class genes

Abstract

Publication series

UN SDGs

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