Distal nephron neoplasms

Stewart Fleming (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Tumours of the distal nephron are uncommon but can create diagnostic difficulties. They may be divided into three groups-tumours of intercalated cell phenotype, those of principal cell phenotype and others with an unconfirmed distal nephron origin. Oncocytomas, chromophobe carcinoma and hybrid oncocytoma chromophobe carcinoma, all show features of intercalated cells and the distinction amongst these is one of the most common areas of diagnostic dilemma. Collecting duct carcinoma and renal medullary carcinoma are the most aggressive forms of renal cancer but recent evidence suggests they may respond to targeted therapy so their recognition becomes crucial to the management of these patients. There remains debate over the precise phenotype of both tubulocystic carcinoma and mucinous tubular and spindle cell carcinoma.

    Original languageEnglish
    Pages (from-to)114-123
    Number of pages10
    JournalSeminars in Diagnostic Pathology
    Volume32
    Issue number2
    DOIs
    Publication statusPublished - Mar 2015

    Fingerprint

    Nephrons
    Oxyphilic Adenoma
    Carcinoma
    Phenotype
    Mucinous Adenocarcinoma
    Neoplasms
    Medullary Carcinoma
    Kidney Neoplasms
    Renal Cell Carcinoma
    Adenocarcinoma
    Therapeutics

    Keywords

    • Chromophobe carcinoma
    • Collecting duct carcinoma
    • Oncocytoma
    • Renal carcinoma
    • Renal medullary carcinoma
    • Tubulocystic carcinoma

    Cite this

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    abstract = "Tumours of the distal nephron are uncommon but can create diagnostic difficulties. They may be divided into three groups-tumours of intercalated cell phenotype, those of principal cell phenotype and others with an unconfirmed distal nephron origin. Oncocytomas, chromophobe carcinoma and hybrid oncocytoma chromophobe carcinoma, all show features of intercalated cells and the distinction amongst these is one of the most common areas of diagnostic dilemma. Collecting duct carcinoma and renal medullary carcinoma are the most aggressive forms of renal cancer but recent evidence suggests they may respond to targeted therapy so their recognition becomes crucial to the management of these patients. There remains debate over the precise phenotype of both tubulocystic carcinoma and mucinous tubular and spindle cell carcinoma.",
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    Distal nephron neoplasms. / Fleming, Stewart (Lead / Corresponding author).

    In: Seminars in Diagnostic Pathology, Vol. 32, No. 2, 03.2015, p. 114-123.

    Research output: Contribution to journalArticle

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    T1 - Distal nephron neoplasms

    AU - Fleming, Stewart

    PY - 2015/3

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    KW - Collecting duct carcinoma

    KW - Oncocytoma

    KW - Renal carcinoma

    KW - Renal medullary carcinoma

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