Distal nephron neoplasms

Stewart Fleming (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    Tumours of the distal nephron are uncommon but can create diagnostic difficulties. They may be divided into three groups-tumours of intercalated cell phenotype, those of principal cell phenotype and others with an unconfirmed distal nephron origin. Oncocytomas, chromophobe carcinoma and hybrid oncocytoma chromophobe carcinoma, all show features of intercalated cells and the distinction amongst these is one of the most common areas of diagnostic dilemma. Collecting duct carcinoma and renal medullary carcinoma are the most aggressive forms of renal cancer but recent evidence suggests they may respond to targeted therapy so their recognition becomes crucial to the management of these patients. There remains debate over the precise phenotype of both tubulocystic carcinoma and mucinous tubular and spindle cell carcinoma.

    Original languageEnglish
    Pages (from-to)114-123
    Number of pages10
    JournalSeminars in Diagnostic Pathology
    Issue number2
    Publication statusPublished - Mar 2015


    • Chromophobe carcinoma
    • Collecting duct carcinoma
    • Oncocytoma
    • Renal carcinoma
    • Renal medullary carcinoma
    • Tubulocystic carcinoma

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine


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