Distribution and causal relationship of FTO rs9939609 and leptin rs7799039 nucleotide variants with type 2 diabetes in a subset of the Bangladeshi population

Mahbubur Rahman, Sabrina Islam, Abu Ashfaqur Sajib, Abdullah Al Emran, Gowranga Kumar Paul, Abul Kalam Azad Chowdhury, Colin Neil Alexander Palmer, Khandoker Mohammad Kaderi Kibria (Lead / Corresponding author), Sabina Yeasmin (Lead / Corresponding author)

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Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder in which blood glucose level remains persistently higher than the physiologically normal range. Two important genes, namely fat mass and obesity-related gene (FTO) and Leptin (LEP), are involved with obesity and progression to diabetes. The aim of this study is to identify the underlying genetic make-up that predisposes individuals to T2DM, namely, rs9939609 and rs7799039 variants of FTO and LEP genes, respectively, were analyzed in a subset of the Bangladeshi population. DNA samples were collected from Blood samples, and the genetic polymorphisms were identified using allele-specific polymerase chain reactions (AS-PCR). The data collected by a standard questionnaire were then analyzed by SPSS for Windows. A total of 257 Bangladeshi individuals were included in the study, among whom 158 were T2DM patients, and 99 were non-diabetic healthy controls. Logistic regression analysis showed that the homozygous FTO rs9939609 variant genotype is significantly associated with type 2 diabetes (P=0.006) in the Bangladeshi population. Meanwhile, the Leptin rs7799039 variant is significantly associated with T2DM in males (P=0.006) but not in females. No association was observed for these variants with body mass index (BMI) and hypertension. The inheritance model analyses showed that the FTO co-dominant, dominant and recessive models are associated with T2D. The study revealed that the FTO rs9939609 variants have a significant role, and Leptin rs7799039 variants have a male-specific effect on T2D of Bangladeshi subjects.

Original languageEnglish
Pages (from-to)113-125
Number of pages13
JournalRomanian Journal of Diabetes, Nutrition and Metabolic Diseases
Volume31
Issue number2
DOIs
Publication statusPublished - 30 Jun 2024

Keywords

  • BMI
  • FTO
  • leptin
  • rs7799039
  • rs9939609
  • type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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