TY - JOUR
T1 - Distribution and causal relationship of FTO rs9939609 and leptin rs7799039 nucleotide variants with type 2 diabetes in a subset of the Bangladeshi population
AU - Rahman, Mahbubur
AU - Islam, Sabrina
AU - Sajib, Abu Ashfaqur
AU - Emran, Abdullah Al
AU - Paul, Gowranga Kumar
AU - Chowdhury, Abul Kalam Azad
AU - Alexander Palmer, Colin Neil
AU - Kaderi Kibria, Khandoker Mohammad
AU - Yeasmin, Sabina
N1 - Publisher Copyright:
© 2024 The Authors.
PY - 2024/6/30
Y1 - 2024/6/30
N2 - Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder in which blood glucose level remains persistently higher than the physiologically normal range. Two important genes, namely fat mass and obesity-related gene (FTO) and Leptin (LEP), are involved with obesity and progression to diabetes. The aim of this study is to identify the underlying genetic make-up that predisposes individuals to T2DM, namely, rs9939609 and rs7799039 variants of FTO and LEP genes, respectively, were analyzed in a subset of the Bangladeshi population. DNA samples were collected from Blood samples, and the genetic polymorphisms were identified using allele-specific polymerase chain reactions (AS-PCR). The data collected by a standard questionnaire were then analyzed by SPSS for Windows. A total of 257 Bangladeshi individuals were included in the study, among whom 158 were T2DM patients, and 99 were non-diabetic healthy controls. Logistic regression analysis showed that the homozygous FTO rs9939609 variant genotype is significantly associated with type 2 diabetes (P=0.006) in the Bangladeshi population. Meanwhile, the Leptin rs7799039 variant is significantly associated with T2DM in males (P=0.006) but not in females. No association was observed for these variants with body mass index (BMI) and hypertension. The inheritance model analyses showed that the FTO co-dominant, dominant and recessive models are associated with T2D. The study revealed that the FTO rs9939609 variants have a significant role, and Leptin rs7799039 variants have a male-specific effect on T2D of Bangladeshi subjects.
AB - Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder in which blood glucose level remains persistently higher than the physiologically normal range. Two important genes, namely fat mass and obesity-related gene (FTO) and Leptin (LEP), are involved with obesity and progression to diabetes. The aim of this study is to identify the underlying genetic make-up that predisposes individuals to T2DM, namely, rs9939609 and rs7799039 variants of FTO and LEP genes, respectively, were analyzed in a subset of the Bangladeshi population. DNA samples were collected from Blood samples, and the genetic polymorphisms were identified using allele-specific polymerase chain reactions (AS-PCR). The data collected by a standard questionnaire were then analyzed by SPSS for Windows. A total of 257 Bangladeshi individuals were included in the study, among whom 158 were T2DM patients, and 99 were non-diabetic healthy controls. Logistic regression analysis showed that the homozygous FTO rs9939609 variant genotype is significantly associated with type 2 diabetes (P=0.006) in the Bangladeshi population. Meanwhile, the Leptin rs7799039 variant is significantly associated with T2DM in males (P=0.006) but not in females. No association was observed for these variants with body mass index (BMI) and hypertension. The inheritance model analyses showed that the FTO co-dominant, dominant and recessive models are associated with T2D. The study revealed that the FTO rs9939609 variants have a significant role, and Leptin rs7799039 variants have a male-specific effect on T2D of Bangladeshi subjects.
KW - BMI
KW - FTO
KW - leptin
KW - rs7799039
KW - rs9939609
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85205586748&partnerID=8YFLogxK
U2 - 10.46389/rjd-2024-1386
DO - 10.46389/rjd-2024-1386
M3 - Article
AN - SCOPUS:85205586748
SN - 1583-8609
VL - 31
SP - 113
EP - 125
JO - Romanian Journal of Diabetes, Nutrition and Metabolic Diseases
JF - Romanian Journal of Diabetes, Nutrition and Metabolic Diseases
IS - 2
ER -