Distribution of mRNA encoding the inwardly rectifying K+ channel, BIR1 in rat tissues

A K Dixon, A K Gubitz, M L Ashford, P J Richardson, T C Freeman

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    The distribution of mRNA encoding the inwardly rectifying K+ channel, BIR1 [1] was investigated in rat tissues, and a comparison made with the expression of related genes rcKATP and GIRK1 using the reverse transcription-polymerase chain reaction (RT-PCR). This showed BIR1 to be expressed in all areas of the brain examined, in the eye but not in any other peripheral tissue. This pattern was distinct from rcKATP and GIRK1. Additional in situ hybridisation studies of the central expression of BIR1 demonstrated high levels of BIR1 mRNA in the hippocampus, dentate gyrus, taenia tecta and cerebellum and at lower levels in the cortex, habenular nucleus, olfactory bulb, primary olfactory cortex, thalamus, pontine nucleus and amygdaloid nucleus.
    Original languageEnglish
    Pages (from-to)135-40
    Number of pages6
    JournalFEBS Letters
    Volume374
    Issue number1
    DOIs
    Publication statusPublished - 23 Oct 1995

    Keywords

    • Animals
    • Brain
    • Potassium Channels
    • G Protein-Coupled Inwardly-Rectifying Potassium Channels
    • RNA, Messenger
    • Rats
    • DNA Probes
    • Polymerase Chain Reaction
    • Rats, Sprague-Dawley
    • Base Sequence
    • In Situ Hybridization
    • DNA Primers
    • Potassium Channels, Inwardly Rectifying
    • Molecular Sequence Data

    Fingerprint Dive into the research topics of 'Distribution of mRNA encoding the inwardly rectifying K+ channel, BIR1 in rat tissues'. Together they form a unique fingerprint.

  • Cite this