Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells

John A. Peters; Tim G. Hales; Jeremy J. Lambert

doi:10.1016/0014-2999(88)90550-X

Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells

John A. Peters, Tim G. Hales, Jeremy J. Lambert

University of Dundee

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

The influence of extracellular calcium and magnesium ion concentrations upon 5-HT₃ receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca²⁺ or Mg²⁺ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.

Original language	English
Pages (from-to)	491-495
Number of pages	5
Journal	European Journal of Pharmacology
Volume	151
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(88)90550-X
Publication status	Published - 14 Jul 1988

Keywords

5-HT
Divalent cations
GR 38032F
N1E-115 neuroblastom cells

ASJC Scopus subject areas

Pharmacology

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title = "Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells",

abstract = "The influence of extracellular calcium and magnesium ion concentrations upon 5-HT3 receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca2+ or Mg2+ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.",

keywords = "5-HT, Divalent cations, GR 38032F, N1E-115 neuroblastom cells",

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AU - Peters, John A.

AU - Hales, Tim G.

AU - Lambert, Jeremy J.

PY - 1988/7/14

Y1 - 1988/7/14

N2 - The influence of extracellular calcium and magnesium ion concentrations upon 5-HT3 receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca2+ or Mg2+ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.

AB - The influence of extracellular calcium and magnesium ion concentrations upon 5-HT3 receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca2+ or Mg2+ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.

KW - 5-HT

KW - Divalent cations

KW - GR 38032F

KW - N1E-115 neuroblastom cells

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U2 - 10.1016/0014-2999(88)90550-X

DO - 10.1016/0014-2999(88)90550-X

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SN - 0014-2999

VL - 151

SP - 491

EP - 495

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells

Abstract

Keywords

ASJC Scopus subject areas

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