Diverse regulatory roles for lysosomal proteases in the immune response

Jeff D. Colbert, Stephen P. Matthews, Gail Miller, Colin Watts

    Research output: Contribution to journalReview articlepeer-review

    84 Citations (Scopus)

    Abstract

    The innate and adaptive immune system utilise endocytic protease activity to promote functional immune responses. Cysteine and aspartic proteases (cathepsins) constitute a subset of endocytic proteases, the immune function of which has been described extensively. Although historically these studies have focused on their role in processes such as antigen presentation and zymogen processing within the endocytic compartment, recent discoveries have demonstrated a critical role for these proteases in other intracellular compartments, and within the extracellular milieu. It has also become clear that their pattern of expression and substrate specificities are more diverse than was first envisaged. Here, we discuss recent advances addressing the role of lysosomal proteases in various aspects of the immune response. We pay attention to reports demonstrating cathepsin activity outside of its canonical endosome/lysosome microenvironment.

    Original languageEnglish
    Pages (from-to)2955-2965
    Number of pages11
    JournalEuropean Journal of Immunology
    Volume39
    Issue number11
    DOIs
    Publication statusPublished - Nov 2009

    Keywords

    • Cathepsins
    • Endosomes
    • Immune regulation
    • Lysosomes
    • DIPEPTIDYL PEPTIDASE-I
    • T-CELL SELECTION
    • COMPLEX CLASS-II
    • CATHEPSIN-L
    • INVARIANT CHAIN
    • DENDRITIC CELLS
    • ANTIGEN PRESENTATION
    • CYSTATIN-F
    • ASPARAGINE ENDOPEPTIDASE
    • B-LYMPHOCYTES

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