Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

Samar Kabbara, Anaïs Hérivaux, Thomas Dugé de Bernonville, Vincent Courdavault, Marc Clastre, Amandine Gastebois, Marwan Osman, Monzer Hamze, J. Mark Cock, Pauline Schaap, Nicolas Papon (Lead / Corresponding author)

Research output: Contribution to journalArticle

6 Citations (Scopus)
192 Downloads (Pure)

Abstract

Histidine kinases (HKs) are primary sensor proteins that act in cell signaling pathways generically referred to as "two component systems" (TCSs). TCSs are among the most widely distributed transduction systems used by both prokaryotic and eukaryotic organisms to detect and respond to a broad range of environmental cues. The structure and distribution of HK proteins are now well documented in prokaryotes but information is still fragmentary for eukaryotes. Here, we have taken advantage of recent genomic resources to explore the structural diversity and the phylogenetic distribution of HKs in the prominent eukaryotic supergroups. Searches of the genomes of 67 eukaryotic species spread evenly throughout the phylogenetic tree of life identified 748 predicted HK proteins. Independent phylogenetic analyses of predicted HK proteins were carried out for each of the major eukaryotic supergroups. This allowed most of the compiled sequences to be categorised into previously described HK groups. Beyond the phylogenetic analysis of eukaryotic HKs, this study revealed some interesting findings: (i) characterisation of some previously undescribed eukaryotic HK groups with predicted functions putatively related to physiological traits; (ii) discovery of HK groups that were previously believed to be restricted to a single kingdom in additional supergroups and (iii) indications that some evolutionary paths have led to the appearance, transfer, duplication, and loss of HK genes in some phylogenetic lineages. This study provides an unprecedented overview of the structure and distribution of HKs in the Eukaryota and represents a first step towards deciphering the evolution of TCS signaling in living organisms.

Original languageEnglish
Pages (from-to)86-108
Number of pages23
JournalGenome Biology and Evolution
Volume11
Issue number1
Early online date25 Sep 2018
DOIs
Publication statusPublished - Jan 2019

Keywords

  • Cell signaling
  • Eukaryotes
  • Histidine kinases
  • Phylogenetic analysis
  • Two-component systems

Fingerprint Dive into the research topics of 'Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes'. Together they form a unique fingerprint.

  • Cite this

    Kabbara, S., Hérivaux, A., Dugé de Bernonville, T., Courdavault, V., Clastre, M., Gastebois, A., Osman, M., Hamze, M., Cock, J. M., Schaap, P., & Papon, N. (2019). Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes. Genome Biology and Evolution, 11(1), 86-108. https://doi.org/10.1093/gbe/evy213