DNA breaks as triggers for antigenic variation in African trypanosomes

Sam Alsford, David Horn, Lucy Glover

    Research output: Contribution to journalReview article

    3 Citations (Scopus)

    Abstract

    The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

    Original languageEnglish
    Article numberARTN 223
    Number of pages4
    JournalGenome Biology
    Volume10
    Issue number6
    DOIs
    Publication statusPublished - 2009

    Keywords

    • RECOMBINATION
    • DOUBLE-STRAND BREAKS
    • SEQUENCES
    • TRANSPOSITION
    • EXPRESSION SITES
    • REPEATS
    • TELOMERES
    • VSG GENE
    • CONVERSION
    • BRUCEI

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