DNA breaks as triggers for antigenic variation in African trypanosomes

Sam Alsford, David Horn, Lucy Glover

    Research output: Contribution to journalReview article

    3 Citations (Scopus)

    Abstract

    The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

    Original languageEnglish
    Article numberARTN 223
    Number of pages4
    JournalGenome Biology
    Volume10
    Issue number6
    DOIs
    Publication statusPublished - 2009

    Keywords

    • RECOMBINATION
    • DOUBLE-STRAND BREAKS
    • SEQUENCES
    • TRANSPOSITION
    • EXPRESSION SITES
    • REPEATS
    • TELOMERES
    • VSG GENE
    • CONVERSION
    • BRUCEI

    Cite this

    @article{d1918eff636243f7b92212007d141770,
    title = "DNA breaks as triggers for antigenic variation in African trypanosomes",
    abstract = "The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.",
    keywords = "RECOMBINATION, DOUBLE-STRAND BREAKS, SEQUENCES, TRANSPOSITION, EXPRESSION SITES, REPEATS, TELOMERES, VSG GENE, CONVERSION, BRUCEI",
    author = "Sam Alsford and David Horn and Lucy Glover",
    year = "2009",
    doi = "10.1186/gb-2009-10-6-223",
    language = "English",
    volume = "10",
    journal = "Genome Biology",
    issn = "1474-7596",
    publisher = "BioMed Central",
    number = "6",

    }

    DNA breaks as triggers for antigenic variation in African trypanosomes. / Alsford, Sam; Horn, David; Glover, Lucy.

    In: Genome Biology, Vol. 10, No. 6, ARTN 223, 2009.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - DNA breaks as triggers for antigenic variation in African trypanosomes

    AU - Alsford, Sam

    AU - Horn, David

    AU - Glover, Lucy

    PY - 2009

    Y1 - 2009

    N2 - The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

    AB - The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

    KW - RECOMBINATION

    KW - DOUBLE-STRAND BREAKS

    KW - SEQUENCES

    KW - TRANSPOSITION

    KW - EXPRESSION SITES

    KW - REPEATS

    KW - TELOMERES

    KW - VSG GENE

    KW - CONVERSION

    KW - BRUCEI

    U2 - 10.1186/gb-2009-10-6-223

    DO - 10.1186/gb-2009-10-6-223

    M3 - Review article

    VL - 10

    JO - Genome Biology

    JF - Genome Biology

    SN - 1474-7596

    IS - 6

    M1 - ARTN 223

    ER -