DNA breaks as triggers for antigenic variation in African trypanosomes

Sam Alsford; David Horn; Lucy Glover

doi:10.1186/gb-2009-10-6-223

DNA breaks as triggers for antigenic variation in African trypanosomes

Sam Alsford
, David Horn
, Lucy Glover

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

Original language	English
Article number	ARTN 223
Number of pages	4
Journal	Genome Biology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1186/gb-2009-10-6-223
Publication status	Published - 2009

Keywords

RECOMBINATION
DOUBLE-STRAND BREAKS
SEQUENCES
TRANSPOSITION
EXPRESSION SITES
REPEATS
TELOMERES
VSG GENE
CONVERSION
BRUCEI

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10.1186/gb-2009-10-6-223

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@article{d1918eff636243f7b92212007d141770,

title = "DNA breaks as triggers for antigenic variation in African trypanosomes",

abstract = "The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.",

keywords = "RECOMBINATION, DOUBLE-STRAND BREAKS, SEQUENCES, TRANSPOSITION, EXPRESSION SITES, REPEATS, TELOMERES, VSG GENE, CONVERSION, BRUCEI",

author = "Sam Alsford and David Horn and Lucy Glover",

year = "2009",

doi = "10.1186/gb-2009-10-6-223",

language = "English",

volume = "10",

journal = "Genome Biology",

issn = "1474-760X",

publisher = "BioMed Central",

number = "6",

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TY - JOUR

T1 - DNA breaks as triggers for antigenic variation in African trypanosomes

AU - Alsford, Sam

AU - Horn, David

AU - Glover, Lucy

PY - 2009

Y1 - 2009

N2 - The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

AB - The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

KW - RECOMBINATION

KW - DOUBLE-STRAND BREAKS

KW - SEQUENCES

KW - TRANSPOSITION

KW - EXPRESSION SITES

KW - REPEATS

KW - TELOMERES

KW - VSG GENE

KW - CONVERSION

KW - BRUCEI

U2 - 10.1186/gb-2009-10-6-223

DO - 10.1186/gb-2009-10-6-223

M3 - Review article

C2 - 19519956

SN - 1474-760X

VL - 10

JO - Genome Biology

JF - Genome Biology

IS - 6

M1 - ARTN 223

ER -

DNA breaks as triggers for antigenic variation in African trypanosomes

Abstract

Keywords

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