DNA fragmentation, antioxidants and ART

Sarah J. Martins Da Silva (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


This chapter includes clinical cases, background, evidence-based practical management options, preventive measures, key-point summaries of DNA fragmentation, antioxidants and assisted reproduction techniques (ART) and answers to questions patients ask. Couples instead rely on ART, usually intracytoplasmic sperm injection, which is expensive, invasive and without guarantee of success. Spermatozoa are particularly sensitive to oxidative stress because of the very small amount of cytoplasm within the cell, therefore possesses limited endogenous antioxidant protection. Sperm DNA damage arising as a consequence of reactive oxygen species is highly prevalent among infertile men and is thought to impair chances of natural conception. Reproductive implications of single strand versus double strand sperm DNA damage are different, with ds DNA damage more likely to have negative impact on ART outcomes.

Original languageEnglish
Title of host publicationAssisted Reproduction Techniques
Subtitle of host publicationChallenges and Management Options
EditorsKhaldoun Sharif, Arri Coomarasamy
ISBN (Electronic)9781119622215
ISBN (Print)9781119622109
Publication statusPublished - 4 Jun 2021


  • antioxidants
  • assisted reproduction techniques
  • DNA fragmentation
  • reproductive implications
  • sperm DNA damage


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