DNA replication licensing factor

James P. J. Chong, J. Julian Blow

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)


    DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.
    Original languageEnglish
    Pages (from-to)83-90
    Number of pages8
    JournalProgress in Cell Cycle Research
    Publication statusPublished - 1996


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