DNA replication licensing factor

James P. J. Chong; J. Julian Blow

DNA replication licensing factor

Research output: Contribution to journal › Article › peer-review

Abstract

DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

Original language	English
Pages (from-to)	83-90
Number of pages	8
Journal	Progress in Cell Cycle Research
Volume	2
Publication status	Published - 1996

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title = "DNA replication licensing factor",

abstract = "DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.",

author = "Chong, {James P. J.} and Blow, {J. Julian}",

year = "1996",

language = "English",

volume = "2",

pages = "83--90",

journal = "Progress in Cell Cycle Research",

issn = "1087-2957",

publisher = "Kluwer Academic/ Plenum Press",

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TY - JOUR

T1 - DNA replication licensing factor

AU - Chong, James P. J.

AU - Blow, J. Julian

PY - 1996

Y1 - 1996

N2 - DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

AB - DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

M3 - Article

C2 - 9552385

SN - 1087-2957

VL - 2

SP - 83

EP - 90

JO - Progress in Cell Cycle Research

JF - Progress in Cell Cycle Research

ER -

DNA replication licensing factor

Abstract

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