It might be possible to treat genetic skin diseases by correcting defective RNA. In this issue of Experimental Dermatology, Bornert et al review the latest developments in this area. Progress is rapid and impressive. Clinical use of RNA correction looks set to soon become reality. The future looks bright indeed. But, as always, we have to think before we act. In my comment, I provide a much-needed reality check. This article is protected by copyright. All rights reserved.