Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

Rebecca Devlin, Catarina A. Marques, Richard McCulloch (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
200 Downloads (Pure)

Abstract

All pathogens must survive host immune attack and, amongst the survival strategies that have evolved, antigenic variation is a particularly widespread reaction to thwart adaptive immunity. Though the reactions that underlie antigenic variation are highly varied, recombination by gene conversion is a widespread approach to immune survival in bacterial and eukaryotic pathogens. In the African trypanosome, antigenic variation involves gene conversion-catalysed movement of a huge number of variant surface glycoprotein (VSG) genes into a few telomeric sites for VSG expression, amongst which only a single site is actively transcribed at one time. Genetic evidence indicates VSG gene conversion has co-opted the general genome maintenance reaction of homologous recombination, aligning the reaction strategy with targeted rearrangements found in many organisms. What is less clear is how gene conversion might be initiated within the locality of the VSG expression sites. Here, we discuss three emerging models for VSG switching initiation and ask how these compare with processes for adaptive genome change found in other organisms.

Original languageEnglish
Pages (from-to)441-449
Number of pages9
JournalCurrent Genetics
Volume63
Issue number3
Early online date7 Nov 2016
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Antigenic variation
  • Trypanosome
  • DNA repair
  • DNA replication
  • Variant surface glycoprotein

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